Tuberculosis

Question 1

How long is Latent TB treated for?

Answer 1

9 months

Question 2

What are the 4 first line drugs for TB?

Answer 2

Isoniazid
Rifampin
Ethambutol
Pyrazinamide

Question 3

What drugs are involved in the Intensive phase of short-course chemotherapy?

Answer 3

4 first line drugs

Question 4

What drugs are involved in the continuation phase of short-course chemotherapy?

Answer 4

Isoniazid

Rifampin

Question 5

What first line drug is specific for treatment of M. tuberculosis and is activated by a mycobacterial catalase–peroxidase (KatG)?

Answer 5

Isoniazid

Question 6

How is Isoniazid impaired when taken?

Answer 6

impaired with high fat meals

Question 7

What is the most serious adverse effect associated with isoniazid?

Answer 7

Hepatitis

Question 8

What first-line drug is never given as a single agent in the treatment of active tuberculosis and blocks RNA transcription by interacting with the β subunit of mycobacterial DNA-dependent RNA polymerase?

Answer 8

Rifampin

Question 9

What first-line drug is active against tuberculosis bacilli in acidic lesions and in macrophages, may contribute to liver toxicity, and is usually discontinued after 2 months of a 6-month regimen?

Answer 9

Pyrazinamide

Question 10

What first-line drug inhibits arabinosyl transferase?

Answer 10

Ethambutol

Question 11

What is the most important adverse effect of Ethambutol?

Answer 11

Optic Neuritis