Antifungals

Question 1

What is the drug of choice for the treatment of several life-threatening mycoses?

Answer 1

Amphotericin B

Question 2

What is the MOA of Amphotericin B?

Answer 2

Form spores that disrupt membrane function resulting in cell death

Question 3

What drug’s adverse effect includes a decrease in glomerular filtration rate and renal tubular function, along with fever and chills, Azotemia, and thromboplebitis?

Answer 3

Amphotericin B

Question 4

Which Azole antifungal is given topically for cutaneous infections?

Answer 4

Imidazoles

Question 5

Which Azole antifungal is given systemically for the treatment or prophylaxis of cutaneous and systemic fungal infections?

Answer 5

Triazoles

Question 6

What enzyme do Azole antifungals inhibit?

Answer 6

Hepatic CYP450 3A4

Question 7

What is the first member of the triazole class of antifungal agents, is the least active of all triazoles, and most of its spectrum is limited to yeasts?

Answer 7

Fluconazole

Question 8

What is Fluconazole the drug of choice for?

Answer 8

Cryptococcus neoformans after induction therapy with amphotericin B

Question 9

What is Fluconazole most effective against?

Answer 9

Mucocutaneous candidiasis

Question 10

What are the most common adverse effects of Fluconazole?

Answer 10

Nausea, vomiting, headache, and skin rashes

Question 11

What broad-spectrum antifungal agent has replaced amphotericin B as the drug of choice for invasive aspergillosis?

Answer 11

Voriconazole

Question 12

What is a common adverse drug reaction to Voriconazole?

Answer 12

Visual and auditory hallucinations and an increased incidence of hepatotoxicity

Question 13

What antifungal agent is the drug of choice for treating dermatophyte onychomycoses (fungal infections of nails)?

Answer 13

Terbinafine

Question 14

What may elevate with Terbinafine use?

Answer 14

serum hepatic transaminases

Question 15

What antifungal agent requires a long duration of treatment, is dependent on the rate of replacement of healthy skin and nails, and concentrates in skin, hair, nails, and adipose tissue?

Answer 15

Griseofulvin

Question 16

What antifungal agent is used for the treatment of cutaneous and oral Candida infections and is used as an oral agent (“swish and swallow” or “swish and spit”) for the treatment of oropharyngeal candidiasis (thrush), intravaginally for vulvovaginal candidiasis, or topically for cutaneous candidiasis?

Answer 16

Nystatin