Anticancer

Question 1

What indication of chemotherapy is the primary treatment for many hematologic cancers and for advanced solid tumors for which no alternative treatment exists?

Answer 1

Primary induction chemo

Question 2

What indication of chemotherapy serves as an important adjuvant to local treatment procedures such as radiation or surgery?

Answer 2

Adjuvant chemotherapy

Question 3

What indication of chemotherapy is given prior to the surgical procedure in an attempt to shrink the cancer?

Answer 3

Neoadjuvant chemotherapy

Question 4

What indication of chemotherapy is given in lower doses to assist in prolonging a remission?

Answer 4

Maintenance chemotherapy

Question 5

What type of chemotherapeutic agents are effective only against replicating cells (cells that are dividing)?

Answer 5

Cell cycle specific

Question 6

What type of chemotherapeutic agents are generally more toxic in cycling cells and are also useful against tumors that have a low percentage of replicating cells?

Answer 6

Cell cycle nonspecific

Question 7

What is it called when a given dose of drug destroys a constant fraction of cells rather than a number of cells and kills a fixed percentage of tumor cells to not a fixed number?

Answer 7

Log Kill Phenomenon

Question 8

T/F: Combination drug chemotherapy is more successful than single-drug treatment in most of the cancers for which chemotherapy is effective

Answer 8

True

Question 9

What type of drugs are combined at full doses?

Answer 9

Cytotoxic agents with qualitatively different toxicities and different molecular sites/MOAs

Question 10

Which type of drugs are combined safely only by reducing the doses of each?

Answer 10

agents with similar dose-limiting toxicities

Question 11

What is the therapeutic index of most anticancer drugs?

Answer 11

narrow

Question 12

What drug has adverse effects such as mucositis, alopecia, myelosuppression, and even renal damage?

Answer 12

Methotrexate

Question 13

What is activated to toxic nucleotides that inhibit several enzymes involved in purine metabolism and is widely distributed throughout the body except the CSF?

Answer 13

6-MP

Question 14

What enzyme metabolizes 6-MP and where?

Answer 14

xanthine oxidase in the liver

Question 15

What is the Adverse drug reaction to 6-MP

Answer 15

Bone marrow suppression

Question 16

What anti-cancer drug’s MOA is to inhibit thymidylate synthase and leads to thymineless death of cells and also inhibits DNA synthesis and function and RNA processing and function?

Answer 16

5-FU (5-Fluorouracil)

Question 17

What intercalates between DNA base pairs, inhibit topoisomerase II, and generate free radicals and block the synthesis of RNA and DNA and cause DNA strand scission?

Answer 17

Anthracyclines Antibiotics

Question 18

What is the most severe ADR of Anthracyclines Antibiotics?

Answer 18

Cardiotoxicity

Question 19

What alkylating agent ADR is Hemorrhagic cystitis along with Cardiac dysfunction and pulmonary toxicity?

Answer 19

Cyclophosphamide

Question 20

What alkylating agent ADR is Neurotoxic ( peripheral neuritis and acoustic nerve damage) and Nephrotoxic
(renal damage)?

Answer 20

Cisplatin

Question 21

What natural product’s ADR can cause neutropenia, thrombocytopenia, and a high incidence of peripheral neuropathy?

Answer 21

Paclitaxel

Question 22

What anti-inflammatory corticosteroid is primarily employed to induce remission in patients with acute lymphocytic leukemia and in the treatment of both Hodgkin and non-Hodgkin lymphomas and is used along with chemo agents (not by itself?

Answer 22

Prednisone

Question 23

What steroid agent is used for first-line therapy in the treatment of estrogen receptor–positive breast cancer and is used prophylactically in reducing breast cancer occurrence in women who are at high risk?

Answer 23

Tamoxifen

Question 24

What are the ADRs of Tamoxifen?

Answer 24

vaginal bleeding and discharge, hypercalcemia, increased pain if the tumor has metastasized to bone

Question 25

What class of drugs are used in the treatment of breast cancer in postmenopausal women and gynecomastia in men?

Answer 25

Aromatase Inhibitors

Question 26

What Monoclonal antibody targets the extracellular domain of the HER2 growth receptor that has intrinsic tyrosine kinase activity?

Answer 26

Trastuzumab

Question 27

What is the most serious toxicity of Trastuzmab?

Answer 27

Congestive Heart Failure