Migraines Flashcards
What is the most common trigger of Migraines?
Emotional Stress
What theory of migraine is self-propagating wave of neuronal and glial depolarization that spreads across the cerebral cortex and This spreading is thought to cause the aura, activate the trigeminal nerve afferents causing inflammation of the pain sensitive meninges, and alter blood-brain-barrier permeability?
Cortical spreading depression
What theory of Migraines is decreased serotonin levels linked to migraines?
Serotonergic abnormalities
What drug is the first available Triptan, is the prototype of this class and is effective in acute migraines?
Sumatriptan
What is Sumatriptan derived from?
Serotonin
What is Sumatriptan metabolized by?
MOA-A
What drug counteracts episodic dilation of extracranial arteries and arterioles?
Ergotamine
What drug is an alpha-adrenergic blocking agent with a direct stimulating effect on smooth muscle of peripheral and cranial blood vessels?
Dihydroergotamine
What Anti-epileptic is useful as a first line agent, is believed to enhance GABA neurotransmission, and is a good mood stabilizer and can benefit patients with concomitant mood swings?
Valproic acid
What may be beneficial in patients with intractable, chronic migraine that has failed to respond to at least 3 conventional preventive medications and is now recommended for the management of chronic migraine?
Botox
How long can the anti-migraine effect last with Botox?
3 months
What is the first monoclonal antibody that binds to the CGRP receptor and is approved for Migraine prophylaxis?
Erenumab
What may prevent migraines by blocking vasodilators, decreasing platelet adhesiveness and aggregation, stabilizing the membrane, and increasing the release of oxygen to tissues?
Beta Blockers (Propranolol)
