Estrogen and Androgens

Question 1

What is the most potent estrogen produced and secreted by the ovary and is the principal estrogen in premenopausal women?

Answer 1

Estradiol

Question 2

What is the primary circulating estrogen after menopause?

Answer 2

Estrone

Question 3

What is present in significant amounts during pregnancy, because it is synthesized by the placenta?

Answer 3

Estriol

Question 4

What are Estrogens and progesterone used for?

Answer 4

Contraception

Postmenopausal hormone therapy

Question 5

T/F: synthetic estrogens are fat soluble

Answer 5

True

Question 6

What are the most common adverse effects of estrogen therapy?

Answer 6

Nausea and breast tenderness

Question 7

What is the primary indication for estrogen therapy in postmenopausal women?

Answer 7

postmenopausal symptoms (hot flashes) and vaginal atrophy

Question 8

What is always included with the estrogen therapy for women with an intact uterus?

Answer 8

Progesterone

Question 9

What drug is currently used in the treatment of metastatic breast cancer, or as adjuvant therapy following mastectomy or radiation for breast cancer?

Answer 9

Tamoxifen

Question 10

What drug is approved for the prevention and treatment of osteoporosis in postmenopausal women?

Answer 10

Raloxifene

Question 11

What drug is used in the treatment of infertility?

Answer 11

Clomiphene

Question 12

The decline of what stimulates the onset of menstruation?

Answer 12

Progesterone

Question 13

What is an injectable contraceptive and is a common progestin component of postmenopausal HT?

Answer 13

Medroxyprogesterone acetate

Question 14

What progestin raises serum potassium levels?

Answer 14

Drospirenone

Question 15

What drug is a progesterone antagonist and is administered for termination of pregnancy?

Answer 15

Mifepristone

Question 16

What is the most common type of oral contraceptive?

Answer 16

combination of estrogen and progestin

Question 17

What is the most common estrogen in combination pills?

Answer 17

Ethinyl estradiol

Question 18

What kind of combination pills contain a constant dose of estrogen and progestin given over 21 to 24 days?

Answer 18

Monophasic

Question 19

What kind of oral contraceptive products attempt to mimic the natural female cycle and usually contain a constant dose of estrogen with increasing doses of progestin given over 21 days?

Answer 19

Triphasic

Question 20

What days are most oral contraceptives taken?

Answer 20

21-24 days

Question 21

What drug is used for postcoital contraception (emergency contraception a.k.a. the morning after pill)?

Answer 21

levonorgestrel

Question 22

What is the most important androgen in humans?

Answer 22

Testosterone