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Pharmacology II > Estrogen and Androgens > Flashcards

Estrogen and Androgens Flashcards

1
Q

What is the most potent estrogen produced and secreted by the ovary and is the principal estrogen in premenopausal women?

A

Estradiol

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2
Q

What is the primary circulating estrogen after menopause?

A

Estrone

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3
Q

What is present in significant amounts during pregnancy, because it is synthesized by the placenta?

A

Estriol

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4
Q

What are Estrogens and progesterone used for?

A

Contraception

Postmenopausal hormone therapy

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5
Q

T/F: synthetic estrogens are fat soluble

A

True

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6
Q

What are the most common adverse effects of estrogen therapy?

A

Nausea and breast tenderness

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7
Q

What is the primary indication for estrogen therapy in postmenopausal women?

A

postmenopausal symptoms (hot flashes) and vaginal atrophy

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8
Q

What is always included with the estrogen therapy for women with an intact uterus?

A

Progesterone

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9
Q

What drug is currently used in the treatment of metastatic breast cancer, or as adjuvant therapy following mastectomy or radiation for breast cancer?

A

Tamoxifen

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10
Q

What drug is approved for the prevention and treatment of osteoporosis in postmenopausal women?

A

Raloxifene

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11
Q

What drug is used in the treatment of infertility?

A

Clomiphene

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12
Q

The decline of what stimulates the onset of menstruation?

A

Progesterone

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13
Q

What is an injectable contraceptive and is a common progestin component of postmenopausal HT?

A

Medroxyprogesterone acetate

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14
Q

What progestin raises serum potassium levels?

A

Drospirenone

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15
Q

What drug is a progesterone antagonist and is administered for termination of pregnancy?

A

Mifepristone

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16
Q

What is the most common type of oral contraceptive?

A

combination of estrogen and progestin

17
Q

What is the most common estrogen in combination pills?

A

Ethinyl estradiol

18
Q

What kind of combination pills contain a constant dose of estrogen and progestin given over 21 to 24 days?

A

Monophasic

19
Q

What kind of oral contraceptive products attempt to mimic the natural female cycle and usually contain a constant dose of estrogen with increasing doses of progestin given over 21 days?

A

Triphasic

20
Q

What days are most oral contraceptives taken?

A

21-24 days

21
Q

What drug is used for postcoital contraception (emergency contraception a.k.a. the morning after pill)?

A

levonorgestrel

22
Q

What is the most important androgen in humans?

A

Testosterone

Pharmacology II (23 decks)

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