Tuberculosis Flashcards

1
Q

rank of PH in most tuberculosis cases

A

4th

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2
Q

Why is there an increase of Tuberculosis

A
  1. limited diagnostic capacity
  2. limited treatment
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3
Q

Why did TB rise after COVID pandemic?

A

co-morbidity

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4
Q

Can TB be also found in milk and milk products?

A

YES

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5
Q

Disease associated with TB

A

Diabetes

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6
Q

Why did TB cases decline during pandemic?

A

• underdiagnosed
• poor reporting
• focused on COVID

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7
Q

TB is ___% cause of multidrug resistance (2019)

A

30%

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8
Q

TB for animal - humans

A

Mycobacterium Tuberculosis Complex (MBTC)

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9
Q

2 TB spp for human - animals (zooanthroponoses)

[ ta ]

A

M. tuberculosis
M. africanum

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10
Q

TB spp where cattles are both maintenance & incidental host

A

M. caprae

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11
Q

TB spp for rodents

A

M. microti

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12
Q

TB spp for goats

A

M. bovis

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13
Q

TB spp of sea animals

A

M. pinnipedii

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14
Q

TB spp of large ruminants & NHP

A

M. orygis

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15
Q

TB spp in Asia

A

M. bovis

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16
Q

ID of TB

A

less than 10

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17
Q

Can TB be latent?

A

YES (5-10% of healthy individuals)

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18
Q

zoonotic mycobacteria usually causes ____ disease

A

extrapulmonary (abdominal & CNS)

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19
Q

Risk factor of TB:
• young or old?
• male or female?
• population density?

A

• Young
• Female (milk)
• high population

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20
Q

disease of M. tuberculosis

A

cutaneous tuberculosis

  • tuberculosis chancre
  • tuberculosis verruccose cutie
  • butcher’s wart
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21
Q

can cutaneous tuberculosis ulcer heal?

A

NO (non-healing ulcer)

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22
Q

When do subclinical TB manifest?

A
  • under stress
  • immunocompromised
23
Q

TB is less common in these 3 animals

x CTH x

A

Cats
Dog
Horse

24
Q

uncalcified nodule itsura

A

liquid-y

25
Q

(2) TB lesion in horses

A
  1. spleen
  2. liver
26
Q

is TB in birds encapsulated?

A

NO

27
Q

TB in this animal is
• slow
• chronic
• debilitating
• lymphadenopathy

A

Cattle

28
Q

TB in this animal are usually asymptomatic but can cause sudden death

A

Birds

29
Q

TB in this animal affects “abdominal area”

A

Horse

30
Q

TB in this animal affects “CNS”

A

Pigs

31
Q

TB in this animal affects “submandibular”

A

Cats

32
Q

Infects cattle in airborne transmission (tumatayo bigla)

A

opposum

33
Q

bacterial culture for TB

A
  1. modified Middlebrook 7H10 / 7H11
  2. Stonebrink’s / Lowenstein-Jensen egg-based medium
34
Q

IP required for Lowenstein-Jensen

A

atleast 2 weeks

35
Q

nawawala curved feature pag inoculated from medium

A

sputum

36
Q

samples for TB

A

pooled lymph node (head & thorax)

  1. milk
  2. feces
  3. urine
37
Q

stain for direct microscopy for TB

A

Ziehl-Neelsen stain

38
Q

genes of M. bovis (2)

A
  1. pncA
  2. oxyR
39
Q

worldwide spoligotyping for M. bovis

A

SB 012 0

40
Q

False-Positive for tuberculin skin test

A

M. avium

41
Q

Tuberculin skin test is for all animals susceptible to TB

A

NO (cattle only)

42
Q

more convenient test than CIT

A

Caudal fold test

43
Q

higher sensitivity & specificity than CFT

A

Cervical INTRAdermal test

44
Q

Caudal fold test is only for this species

A

M. bovis

45
Q

Substitute test than tuberculin skin test

A

Gamma-interferin release assay

46
Q

detects interferon-gamma

A

Primary coating antibody

47
Q

in ELISPOT assay, this forms color changes

A

precipitated enzyme SUBSTRATE

48
Q

(2) resistant for TB

x IR x

A

Isoniazid
Rifampicin

49
Q

M. bovis is innately resistant to

A

pyrazinamide

50
Q

Min treatment for M. bovis

A

9 months

51
Q

To prevent TB, cook meat for:

A

65C ; atleast 30 mins

52
Q

autoclave for TB

A

121C ; atleast 15 mins

53
Q

strain of vaccine for TB (route?)

M. tuberculosis

A

Bacillus Calmette Guerin strain (IM, deltoid)

54
Q

vaccine route for M. bovis (cattle)

A

respiratory / SC