Botulism Flashcards
Botulism spp that is F toxin
C. baratii
Botulism spp that is E toxin
C. butyricum
former group IV of C. botulinum
C. argentinenee
Botulism toxins of HUMANS
A, B, E
Botulism toxins of HORSES
toxin B
Botulism toxins of animals
C, D, mosaics
pH for Botulism to grow
more than pH 4.6
for group 3, type C botulism
pH required?
more than 5.1 — 5.4
salt conc needed to grow botulism
LESS than 10%
Nitrate level to inhibit Botulism in Philippines
100 - 200 ppm
Inactivates toxins of botulism (2)
- sunlight (1-3 hrs)
- 0.1% sodium hypochlorite (1% for vegetative cell)
Botulism in northern regions
Type E
most common cause of botulism
Infant botulism
spores ID for Botulism
10-100 spores/kg
paralysis of C. botulism
flaccid paralysis
paralysis of C. tetani
spastic paralysis
no acetylcholine =
no heart contraction
Botulism can be fatal in 1 day
TRUE
drug abusers
cosmetic procedure
black tar heroin (SC)
wound botulism
Age affected with infant botulism (give shedding)
LESS than 1 y.o.
(7 months shedding)
Floppy baby syndrome
Infant botulism
Inhalation of accidental injection of toxin
Iatrogenic (drug-induced)
has higher infectious dose than Foodborne
Inhalation botulism
Important for ruminants to avoid botulism
Phosphorus
Young or Old horse?
YOUNG
Shaker Foal syndrome (foal)
Equine Grass sickness (young adult)
botulism for birds
Limberneck
diagnosis for Botulism
mouse neutralization test
need prior to blood/egg yolk agar culture (2)
- heat
- ethanol treatment
to stop neuromuscular blockage
Guanidine hydro-chloride
Avoid this drug for Botulism
AMINO-glycosides
Botulism for wound debridement & antibiotic therapy
penicillin G or metronidazole
Why hydrogen peroxide for wound botulism?
it is anaerobic
