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VPH 122 (3rd exam) > Plague > Flashcards

Plague Flashcards

1
Q

Plague is mainly a disease of ____

A

rodents

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2
Q

most severe Plague in history

A

Black Death
(75-200M deaths)

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3
Q

3 biovars of Plague

[ amo ]

A

Antiqua
Medievalis
Orientalis

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4
Q

2 biovars in Central Asia

A

Antiqua & Medievalis

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5
Q

biovar in Africa

A

Antiqua

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6
Q

biovar that is widespread

A

Orientalis

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7
Q

most affected place due to Plague

A

Madagascar (endemic)

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8
Q

(2) preferred season of Plague

A
  1. summer
  2. spring

warm temp
high relative humidity

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9
Q

Occurence of Plague

A

• remote places
• delay in dx & tx

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10
Q

Natural disaster & destruction of habitat caused widespread of ___, increasing Plague transmission.

A

fleas

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11
Q

Incidental host for plague

A

Humans

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12
Q

Plague

vector —
IH —

A

vector — fleas
IH — rodents

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13
Q

optimal growth temp of Plague

A

30 C (capable at 4C — 41C)

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14
Q

What fomites can Plague survive in? (2)

A

soil
steel

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15
Q

ID of Plague?

clue - low

A

1 - 10

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16
Q

(4) diseases of Plagues in HUMANS

A
  1. Bubonic
  2. Septicemic
  3. Pneumonic
  4. Rare
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17
Q

(2) diseases caused by flea bite

A
  1. Bubonic
  2. Septicemic
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18
Q

more common septicemic form

A

2 Septicemic (secondary)

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19
Q

(1) primary septicemic form

[ ehp ]

A
  1. epistaxis
  2. hematuria
  3. petechiae
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20
Q

the zoonotic Plague

A

Septicemic form

21
Q

Human-Human transmission Plague caused by:

primary — INHALATION
secondary — infected blood to LUNGS

A

Pneumonic form

22
Q

most common Plague

A

Bubonic

23
Q

self-limiting plague

A

Rare form (pestis minor)

24
Q

Plague that causes swollen femoral lymph nodes as clinical signs

A

Bubonic form

25
Q

Plague bacteria per:
• blood meal —
• bite —

A

• blood meal — 300
• bite — 20,000

26
Q

Plague case fatality of bubonic form w/o treatment

A

50-70%

27
Q

Plague case fatality of Bubonic form with treatment

A

10-15%

28
Q

Plague case fatality of Septicemic form with treatment

A

40%

29
Q

(2) with 100% case fatality rate w/o treatment

A
  1. Septicemic
  2. Pneumonic
30
Q

100% case fatality rate with or w/o tx

A

Pneumonic form

31
Q

(3) Case definitions of Plague

[ San Pablo City ]

A
  1. Suspected
  2. Presumptive
  3. Confirmed
32
Q

Case definition involved in
• clinical signs
• epidemiological feature
• flea bite evidence
• travel to endemic places in previous 10 days

A

Suspected case

33
Q

consistent with 2 out 4 positive tests
• gram negative coccobacilli
• Wayson / Giemsa
• F1 antigen (ELISA / dipstick)
• single anti-F1 serology

A

Presumptive case

34
Q

In serologic tests, any previous exposure of Plague leads to?

A

false-POSITIVE

35
Q

case with 2 out of 4 positive BACTERIAL CULTURE

A

Confirmed case

36
Q

(2) virus used in lysis of bacteria ng Plague
• 20-25C
• 37C

A
  1. Podo-viridae
  2. Myo-viridae
37
Q

Biochemical profile of Plague

IMViC

A

IMViC
( - | + | - | - )

catalase = (+)

38
Q

most common form of Plague in CATS

A

bubonic form

39
Q

resistant to Plague

A

rodents

40
Q

Type of plague for GOATS & CAMEL

A

OCULAR plague

41
Q

type of hemorr septicemia in rodents with Plague

A

Subclinical / Fulminant

42
Q

Not known to develop Plague

x CHiPS x

A

Cattle
Horse
Pig
Sheep

43
Q

stains for Plague (2)

A
  1. Wright-Giemsa
  2. Wayson
44
Q

samples for nutrient agar of Plague (3)

A
  1. blood
  2. bubo aspirates
  3. sputum
45
Q

interval of latex agglutination for Plague

A

1 - 2 weeks interval

46
Q

most important prevention for Plague

A

early diagnosis

47
Q

1st line of antibiotics for Plague

A

Cotrimoxazole

48
Q

other antibiotics for Plague

[ sdc ]

A

Streptomycin
Doxycycline
Chlorampenicol

49
Q

route of vaccine for high risk group of Plague

give interval

A

IM (weeks 1, 5, 6)

VPH 122 (3rd exam) (26 decks)

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