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VPH 122 (3rd exam) > Shigellosis > Flashcards

Shigellosis Flashcards

1
Q

other name for Shigellosis?

A

Bacillary Dysentery

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2
Q

Shigellosis with 1 infectious dose?

A

S. sonnei

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3
Q

most prevalent Shigellosis?

A

S. dysenteriae

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4
Q

Shigellosis in developing country?

A

S. flexneri

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5
Q

Shigellosis is a gastrointestinal disease primarily in humans and what animals?

A

Non-human primates

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6
Q

Is antibiotic resistance common in Shigella?

A

YES

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7
Q

A healthy man with shigella drinks lots of water. What can happen in 4-7 days?

A

It can be self-limiting

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8
Q

most prevalent risk factor of Shigella in Thailand?

A

renting accomodation

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9
Q

What drug became resistant for Shigella in men who have sex with men and homeless people (Oregon)?

A

azithromycin for S. sonnei

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10
Q

Is Shigella in the Philippines?

A

YES (1980-1984)

S. flexneri (most prevalent)

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11
Q

Shigella invades these 2 epithelium:

A
  1. colonic
  2. rectal
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12
Q

2 spp that produces Shiga toxin

[ df ]

A

1) S. dysenteriae
2) S. flexneri

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13
Q

Infectious dose of Shigella?

A

10 - 200

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14
Q

Shedding span of Shigella?

A

4 weeks

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15
Q

Main route of transmission of Shigella?

A

feco-oral

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16
Q

most frequent acute kidney injury in young children

A

Hemolytic Uremic Syndrome

17
Q

disease caused by S. flexneri

A

Reactive Arthritis

18
Q

Disease caused by S. sonnei

A

Myocarditis

19
Q

What sample should be used in the microscopic exam of Shigella?

20
Q

Specific test for Shigella?

It occurs in 1 day (24hrs) but needs 2 days (48hrs).

A

Ornithine decarboxylase test

21
Q

pH of bromocresol purple

22
Q

pH of cresol red

A

pH 7.0 — 8.8

23
Q

Test for S. dysenteriae

24
Q

(3) Bacterial culture for Shigella

[ MXD ]

A
  1. MacConkey agar
  2. Xylose desoxychocolate agar
  3. Desoxychocolate Citrate agar
25
Q

PCR for Shigella detects these 3 genes

A

ipaH
virF
virA

26
Q

treatment for Shigella?

27
Q

Is anti-motility drugs recommended for Shigella?

A

NO (contraindicated)

28
Q

Infected person with Shigella should stay away for how many weeks in doing recreational water, food activity and other activities?

A

6 weeks at MOST

29
Q

Can Shigella be killed by autoclaving?

A

YES (100C for 1hr)

30
Q

(2) Drugs for children with Shigella?

A
  1. Mecillinam
  2. Ceftriaxone
31
Q

1st line of antibiotics for Shigella?

A

Ciprofloxacin

32
Q

Antibiotics for adults with Shigella?

A

Azithromycin

33
Q

Other drugs recommended for shigella aside from the specific ones mentioned?

A
  1. Fluoroquinolone
  2. 3rd & 4th gen cephalosporin
  3. sulfonamides
  4. nalidixic acid
34
Q

Can asymptomatic infection happen in Shigella?

35
Q

IP of Shigella?

A

12hrs — 3 days
(ave: 3 days)

36
Q

Lactose fermenters shigella?

37
Q

Non-lactose fermenters shigella?

VPH 122 (3rd exam) (26 decks)

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