TTP Flashcards

1
Q

Pathogenesis of Thrombotic Thrombocytopenic purpura

A

deficiency of ADAMTS13 enxyme which breaks down von Willebrand’s factor

=> vWF is able to clump platelets together in vessels without being broken down

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2
Q

Who usually gets TTP?

A

Adult females

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3
Q

Features of TTP

A
  • fever
  • fluctuating neuro signs (microemboli)
  • microangiopathic haemolytic anaemia
  • thrombocytopenia
  • renal failure
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4
Q

Causes of TTP

A

post-infection e.g. urinary, GI, HIV
pregnancy
drugs: ciclosporin, COCP, penicillin, clopidogrel, aciclovir
Tumours
SLE

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5
Q

Management of TTP

A

no antibiotics - may worsen outcome!!

plasma exchange = Tx of choice

steroids
immunosuppressants
vincristine

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6
Q
A
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