Burkitt's Lymphoma Flashcards

1
Q

What type of tumour is Burkitts Lymphoma

A

high-grade B-cell neoplasm

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2
Q

2 major forms of Burkitts

A

endemic (African) form: typically involves maxilla or mandible

sporadic form: abdominal (e.g. ileo-caecal) tumours are the most common form

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3
Q

Sporadic form of Burkitts Lymphoma is more common in patients with what viral condition?

A

More common in patients with HIV

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4
Q

Endemic form of Burkitts is associated with which virus?

A

EBV

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5
Q

Genetics associated with Burkitts

A

c-myc gene translocation

usually t(8:14)

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6
Q

Microscopic appearance of Burkitts

A

‘starry sky’ appearance:

lymphocyte sheets interspersed with macrophages containing dead apoptotic tumour cells

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7
Q

Management of Burkitts

A

Chemotherapy

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8
Q

Chemotherapy in Burkitts causes a rapid response. Why is this a risk?

A

‘tumour lysis syndrome’.

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9
Q

Findings in Tumour Lysis Syndrome

A

hyperkalaemia
hyperphosphataemia
hypocalcaemia
hyperuricaemia
acute renal failure

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9
Q

Prophylaxis of Tumour Lysis Syndrome

A

Rasburicase

converts uric acid to allantoin

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10
Q
A
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