Burkitt's Lymphoma Flashcards
What type of tumour is Burkitts Lymphoma
high-grade B-cell neoplasm
2 major forms of Burkitts
endemic (African) form: typically involves maxilla or mandible
sporadic form: abdominal (e.g. ileo-caecal) tumours are the most common form
Sporadic form of Burkitts Lymphoma is more common in patients with what viral condition?
More common in patients with HIV
Endemic form of Burkitts is associated with which virus?
EBV
Genetics associated with Burkitts
c-myc gene translocation
usually t(8:14)
Microscopic appearance of Burkitts
‘starry sky’ appearance:
lymphocyte sheets interspersed with macrophages containing dead apoptotic tumour cells
Management of Burkitts
Chemotherapy
Chemotherapy in Burkitts causes a rapid response. Why is this a risk?
‘tumour lysis syndrome’.
Findings in Tumour Lysis Syndrome
hyperkalaemia
hyperphosphataemia
hypocalcaemia
hyperuricaemia
acute renal failure
Prophylaxis of Tumour Lysis Syndrome
Rasburicase
converts uric acid to allantoin