Acute Lymphoblastic Leukaemia (ALL)

Question 1

Describe what cells are affected in ALL

Answer 1

• lymphoid progenitor cells

=> lymphoid cells dont mature into B cells/T cells

=> lymphoblasts infiltrate marrow and other tissues

Question 2

Peak age for developement of ALL

Answer 2

2-5 years

Question 3

Good prognostic Factors in ALL

Answer 3

French-American-British (FAB) L1
common ALL
pre-B phenotype
low initial WBC
del(9p)

Question 4

Poor prognostic factors in ALL

Answer 4

FAB L3 type
T or B cell surface markers
Philadelphia translocation, t(9;22)
age < 2 years or > 10 years
male sex
CNS involvement
high initial WBC (e.g. > 100 * 109/l)
non-Caucasian