Myelofibrosis Flashcards
1
Q
What causes myelofibrosis
A
myeloproliferative disorder
- hyperplasia of abnormal megakaryocytes
- release of platelet derived growth factor is thought to stimulate fibroblasts
- haematopoiesis in the liver and spleen
2
Q
Presentation of Myelofibrosis
A
- elderly person
- anaemia
- massive splenomegaly
- hypermetabolic: weight loss, night sweats
3
Q
FBC and biochemical findings in Myelofibrosis
A
anaemia
high WBC and platelet count early in disease
high urate and LDH (increased cell turnover)
4
Q
Blood film finding in myelofibrosis
A
‘tear-drop’ poikilocytes
5
Q
What is seen on bone marrow biopsy in myelofibrosis
A
poor bone marrow biopsy - ‘dry tap’
trephine biopsy needed
6
Q
A
