trimethoprim Flashcards
1
Q
what is it used for?
A
1st choice for UTI
used for pneumnocystic puenomnia - jirovecii, carinii
prostatitis ( as co-trmoxazole)
shigellaosis
2
Q
MOA
A
bacteria cant used external source of folate
this medication inhibits folate synthesis by bacterial
can be used in gram neg and positive
inhibits folate synthesis making them bactercidial
3
Q
caution/contraindicated?
A
1st trimester of pregnancy - associated with increased fetal abnormalities risk
those with folate deficiency
those who are immunocompromised e.g. HIV, elderly
renal impairment
4
Q
SE
A
nausea vomiting sore mouth hypersensitivity reactions-rash megablastic anaemia hyperkalaeimia GI disturbances
aseptic meningitis
5
Q
drug interations?
A
folate antagonists such as methotrexate , phenytoin increase effect of warfarin K elevated drugs - hyperkalemia hyponatremia many can cause nephrotoxicity
6
Q
noticeable interaction?
A
ACEi given with spironolactone
