macrolides Flashcards
1
Q
name a macrolide or two
A
erythromycin
clarithromycin
2
Q
MOA
A
inhibits 50s subunit
prevents translation and elongation of peptide chain
3
Q
SE
A
Gi disturbances Rash/hypersensivity Antibiotic associated colitis Prolonged GT Eosephilia cholestatic jaundice thrombophelibitis
4
Q
CI
A
those at risk of arryhtmias those with liver and renal impairment elderly-risk of c.dificleand colitis hypersensivitiy m. gravis acute porphyria
5
Q
DI
A
increased bleeding risk with warfarin
SSRI - , antipsychotics and amoriodone - arrythmias
myopathy - statins
6
Q
uses
A
CLAW- whooping cough, ligonella, clamydia, camylobacteria,Atypical pnuemonia h.pylori respiratory infections prostatitis severe pneumonia soft skin and respiratory tissue infection rosacea acne diphtheria lyme disease
