gentamicin

Question 1

type of abx?

Answer 1

aminoglycoside

Question 2

moa

Answer 2

inhibits protein synthesis by binding onto 30 subunit and enters bacterial cells by using oxygen transporter system - not present in anaerobes and streptococci so utility here is futile.
can be enhanced with pencillin by increases bacterial uptake as it weakens cell walls

Question 3

uses

Answer 3

arerobic infections -  pseudonoma aerginosa 
endocarditis 
sepsis
intrabdominal sepsis
pyelonephritis and complicated UTI

Question 4

AE

Answer 4

ototoxicity -build up of drug in hair cells
irreversible
nephrotoxicity- renalepithheliel cell build up- decrease output increase creatinine and urea

Question 5

ci

Answer 5

deafness
renal impairment
elderly
neonates

Question 6

precaution

Answer 6

check hearing and renal function prior and after and during
monitor carefully using Hartford nomogram
in obese, use dose based on ideal weight to prevent overdosing

myanthesia gravis due to impaired neuromuscular transmission

Question 7

drug interactions

Answer 7

increase risk of ototoxicity if given with diuretics such as furosemide
increased nephrotoxicity with nephrotoxic drugs, chemotherapy, platinuim, cephalopsori and vancomycin