name two macrolides Flashcards
1
Q
name 2 macrolides
A
erythromycin and clarithromycin
2
Q
uses
A
in combo with pencillin for atypical pneumonia
resp and skin tissue infections
h.yplori with ppi and amoxicillin or metronidazole for eridcation therapy
3
Q
moa
A
inhibits 50s subunit and blocks translocation so subsequent stage of elongation cannot occur
erythromycin has broad spectrum so targets alotof gram pos bacteria
synthetic macrolide have increased use for gram neg
4
Q
AE
A
nausea vomiting abdo pain diarrhoea thrombophlebitis voliyid cholestatic jaundice prolonged QT
5
Q
DI
A
inhbitis cytorhome p450 enzyme therefore drugs metabolised by it can increase in effect such as warfarin increased bleeding risk
statin -myopathy
caution with amidorone, antpsychotics, quiniones and srri may trigger arrythmas
6
Q
CI
A
those with prolonged qt interval
hepatic and renal imapriment
