Trimetaphan (Arfonad) Flashcards

1
Q

Description

A

Nicotinic ganglionic blocker (non-depolarizing), reversible competitive inhibition

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2
Q

Action

A

Blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptors

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3
Q

Indications

A

Rarely used but sometimes for hypertensive crisis or in dissecting an aortic aneurism

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4
Q

Toxicity

A

Very toxic and only used in emergency situations, orthostatic hypotension, urinary retention, constipation, impaired accomodation of lens of the eye

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5
Q

Other Facts

A

Short acting, IV, does not cross BBB

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