Tamsulosin / Flomax Flashcards

1
Q

Cost

A

5-70 per month

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2
Q

Drug Class

A

Pharmacologic Class: selective alpha 1 adrenoceptor blocker;
Therapeutic Class: treatment of obstructive symptoms of BPH

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3
Q

Pharmacodynamics

A

Selectively blocks alpha1 receptors but preferentially in the prostate, leading to relaxation of SM in the bladder neck and prostate, improving urine flow and reducing obstructive symptoms of BPH venoconstriction

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4
Q

Pharmacokinetics

A

Completely absorbed after oral ingestion; >90% metabolized by CYP 450 enzymes; half-life about 6 hours, but duration of action up to 15 hours due to slow absorption

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5
Q

Toxicity

A

Excessive hypotension with syncope, especially orthostatic, especially in patients on diuretics, allergic reactions, decreased libidio

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6
Q

Interactions

A

Additive effects with most other antihypertensives, especially diuretics

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7
Q

Special Considerations

A

Rule out carcinoma of prostate before beginning treatment; do not crush or chew tablets, as that will speed up absorption; can also be used to treat spasm of ureter in patients with kidney stones

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8
Q

Indications and Dose / Route

A

for symptoms of BPH, 0.4 mg po qd or bid; similar doses for renal colic

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9
Q

Monitor

A

BP

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