Tamsulosin / Flomax Flashcards
Cost
5-70 per month
Drug Class
Pharmacologic Class: selective alpha 1 adrenoceptor blocker;
Therapeutic Class: treatment of obstructive symptoms of BPH
Pharmacodynamics
Selectively blocks alpha1 receptors but preferentially in the prostate, leading to relaxation of SM in the bladder neck and prostate, improving urine flow and reducing obstructive symptoms of BPH venoconstriction
Pharmacokinetics
Completely absorbed after oral ingestion; >90% metabolized by CYP 450 enzymes; half-life about 6 hours, but duration of action up to 15 hours due to slow absorption
Toxicity
Excessive hypotension with syncope, especially orthostatic, especially in patients on diuretics, allergic reactions, decreased libidio
Interactions
Additive effects with most other antihypertensives, especially diuretics
Special Considerations
Rule out carcinoma of prostate before beginning treatment; do not crush or chew tablets, as that will speed up absorption; can also be used to treat spasm of ureter in patients with kidney stones
Indications and Dose / Route
for symptoms of BPH, 0.4 mg po qd or bid; similar doses for renal colic
Monitor
BP