Losartan

Question 1

Alternate name and cost

Answer 1

CoZaar; total of 7 in class; 4-74$

Question 2

Drug Class

Answer 2

Pharma: Angiotensin 1 receptor Blocker (ARB)
Therapeutic: antihypertensive, preserve renal function, treatment of CHF

Question 3

Pharmacodynamics

Answer 3

Block stimulation of AT 1 receptor by angiotensin II, thereby reducing vasoconstriction and production of aldosterone

Question 4

Pharmacokinetics

Answer 4

F~30%; onset 6 hr; extensive first pass effect; active metabolite is 40x more potent, much longer half-life

Question 5

Toxicity

Answer 5

Dizziness; orthostatic hypotension; worsening of renal failure

Question 6

Interactions

Answer 6

Additive effects with most other antihypertensives

Question 7

Special Considerations

Answer 7

Pregnancy Class C/D; use care in patients on diuretics, those with renal artery stenosis, those with mitral / aortic stenosis, angioedema in african americans

Question 8

Indications and Dose / Route

Answer 8

For HTN, daily dose 25-100 mg q day

Question 9

Monitor

Answer 9

BP, weight, edema, lytes, BUN, creatinine!!