Botulinum Toxin (BoTox)

Question 1

Description

Answer 1

Bacterial exotoxin, inhibitor of ACh release from nerve terminals

Question 2

Actions

Answer 2

Causes botulism; interferes with docking proteins on the interior of the nerve membrane (vesicles containing ACh cannot dock properly and therefore cannot release AcH)

Question 3

Indications

Answer 3

Remove facial wrinkles and prevent hyperhydrosis (BoTox), migraines

Question 4

Toxicity

Answer 4

BLACK BOX Distant spread of Toxin effect can produce sx consistent w/ botulinum toxin; asthenia (weakness), generalized muscle weakness, diplopia (double vision), ptosis, dysphagia, dysphonia (diff swallowing), dysphonia (diff speaking physically problem), dysarthria, urinary incontinence, breathing difficulty, deaths can be reported; sx occur hours to weeks after injection

Question 5

Other facts

Answer 5

Local injections to prevent systemic effects