Phentolamine / Regitine Flashcards

1
Q

Drug Class (Pharmacologic and Therapeutic)

A

Pharm: Non-selective, competitive alpha-adrenergic receptor blocker
Therapeutic: antihypertensive drug for patients with pheochromocytoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pharmacodynamics

A

Blocks alpha 1 and alpha 2 adrenergic receptors at presynaptic and postsynaptic alpha receptors, decreasing preload and afterload

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pharmacokinetics

A

Only comes in IV formulation, so F=100%; plasma half-life about 20 min after IV dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Toxicity

A

Excessive hypotension with syncope, especially orthostatic, especially in patients on diuretics; allergic reactions; decreased libido

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Interactions

A

Additive effects with most other antihypertensives, especially diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Special Considerations

A

Rule out carcinoma of prostate before beginning treatment, do not crush or chew tablets, as that will speed up absorption; can also be used to treat spasm of ureter in patients with kidney stones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Indications and dose / route

A

Aid in Dx of pheo; treatment of intra-op HTN during pheo removal surgery; prevention of dermal sloughing after extravasation of NE infusion; hypertensive crisis from sympathomimetic amines (discuss tyramine-MAO interaction) ; Dose 5 mg IV, then titrate, repeat as needed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Monitor BP!!!

A

BP!!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly