Atenolol Flashcards

1
Q

Alternate Names

A

Propranolol, Inderal, Inderal LA, metoprolol, Toprol XL many others: COst 4-52$, up to 108$ for Inderal LA

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2
Q

Drug Class

A

Pharm: Beta adrenoceptor blocker (beta 1 specificity)
Therapeutic: antihypertensive, antiarrhthmic, primary and secondary prevention of MI, anti-anginal

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3
Q

Pharmacodynamics

A

Binds directly to beta-receptors, with a preference for Beta1 over beta2 receptors, leading to lower BP via several potential mechanisms (less CO, less RAAS); recent evidence suggests less effective in preventing strokes than other drugs, hence no longer used as initial monotherapy in most patients

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4
Q

Pharmacokinetics

A

Available po or IV, variable oral F; onset 1-2 hours h, duration 12-24 hours, can be given once per day; renally excreted (longer half life)

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5
Q

Toxicity

A

Excessive hypotension; bradycardia; heart block can worsen severe CHF (but indicated for mild to moderate CHF) worsen bronchospasm in severe asthmatics

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6
Q

Interactions

A

Additive effects with most other antihypertensives, additive AV block with CEBs

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7
Q

Special Considerations

A

May be especially useful in HTN patients with exertional angina, MI, atrial fibrillation, watch out for abrupt withdrawal; may no longer be first line drug unless other indications exist

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8
Q

Indications and Dose / Route

A

For treatment of hypertension, 25-100 mg per day, in one or two doses

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9
Q

Monitoring

A

BP, HR, exercise tolerance

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