Treatment of mouth and esophagus infections

Question 1

Most commonly used topical azoles for oral C albicans infection

Answer 1

Clotrimazole
Miconazole

Question 2

Mechanism of Azole drugs

Answer 2

Reduction of ergosterol synthesis by inhibition of fungal CYP450

Question 3

Non-azole topical drug for C albicans infection

Answer 3

Nystatin

Question 4

Drug used for severe C albicans infection

Answer 4

Fluconazole PO or IV

Question 5

Preferred drug for fungal meningitis due to good CSF penetration

Answer 5

Fluconazole

Question 6

Treatment of choice for HSV encephalitis, neonatal HSV, and serious HSV or VZV

Answer 6

Acyclovir

Question 7

Virus requirement for susceptibility for Acyclovir

Answer 7

Virus specific thymidine kinase for drug activation

Question 8

Drugs used to treat HSV

Answer 8

Acyclovir
Valacyclovir
Famciclovir
Penciclovir

Question 9

Mechanism of acyclovir and valacyclovir

Answer 9

Competition with deoxy-GTP for viral DNA polymerase
Chain termination

Question 10

Mechanism of famciclovir and penciclovir

Answer 10

Competitive inhibition of viral DNA polymerase

Question 11

Treatment of Plummer-Vinson syndrome

Answer 11

Iron replacement
Mechanical dilation if indicated