Treatment of GI cancer

Question 1

First line treatment for gastroesophageal cancer

Answer 1

IV 5-FU or PO capecitabine

Fluorouracil based chemotherapy

Question 2

Alternative treatments for gastroesophageal cancer

Answer 2

Cisplatin based regimens
Combined with either irinotecan or a taxane

Question 3

Treatment for metastatic gastroesophageal cancer with overexpression of HER-2/neu receptor

Answer 3

Trastuzumab and cisplatin

Question 4

Treatment of metastatic pancreatic cancer

Answer 4

Gemcitabine

Question 5

Treatment of hepatocellular cancer

Answer 5

Sorafenib

Question 6

Curative modality for localized colon cancer

Answer 6

Surgical removal/colectomy

Question 7

Adjuvant chemotherapy for colon cancer for 6 mos after surgery

Answer 7

Oxaliplatin with 5-FU and leucovorin

Question 8

Cytotoxic agent that is an analog of thymine and works by blocking DNA synthesis by inhibiting DNA polymerase and being incorporated into nascent DNA, causing chain termination.

Answer 8

Fluorouracil
Capecitabine (prodrug)

Question 9

Uses of fluorouracil

Answer 9

Breast ca
Colorectal ca
Gastric ca
SCC of head and neck

Question 10

Uses of capecitabine

Answer 10

Colorectal ca
Breast ca

Question 11

Uses of oxaliplatin

Answer 11

Pancreatic ca
Colorectal ca
Gastroesophageal ca

Question 12

Mechanism of irinotecan

Answer 12

Inhibits topoisomerase I

Question 13

When is irinotecan used in colorectal ca?

Answer 13

Used in recurrence, or in progression after 5-FU therapy

Question 14

Anti-VEGF monoclonal antibody used for treating metastatic colon ca

Answer 14

Bevacizumab

Question 15

Adverse effects of bevacizumab

Answer 15

HTN
Increased thomboembolic events
Slowed wound healing
GI perforations
Proteinuria

Question 16

Anti-EGFR monoclonal antibodies used in treating metastatic colorectal ca expressing KRAS or NRAS

Answer 16

Cetuximab
Panitumumab

Question 17

Adverse effects of cetuximab and panitumumab

Answer 17

Acneiform skin rash
Hypersensitivity infusion reaction
Hypomagnesemia

Question 18

Fusion protein that target VEGF-A, VEGF-B, and PIGF. Used for colorectal ca

Answer 18

Ziv-aflibercept

Question 19

Anti-VEGF-R2 antibody used for colorectal ca.

Answer 19

Ramucirumab

Question 20

Small molecule tyrosine kinase inhibitor used for colorectal ca

Answer 20

Regorafenib

Question 21

Symptoms of carcinoid syndrome

Answer 21

Flushing
Abd pain
Diarrhea
Bronchoconstriction
Carcinoid heart disease

Question 22

Cause of carcinoid syndrome

Answer 22

Release of vasoactive amines into the systemic ciruclation

Question 23

Only potential curative therapy for GI carcinoid tumors

Answer 23

Surgical resection

Question 24

Slow-growing GI tumors that originate in the neuroendocrine cells

Answer 24

Carcinoid tumors

Question 25

Short-acting somatostatin analog used in GI carcinoid tumors

Answer 25

Octreotide

Question 26

Long-acting somatostatin analog used in GI carcinoid tumors

Answer 26

Lanreotide

Question 27

Effect of somatostatin analogs in GI carcinoid tumors

Answer 27

Treat carcinoid syndrome by cAMP inhibition

Question 28

Drug used for inhibition of disease progression and symptom relief in GI carcinoid tumors

Answer 28

Interferon alpha