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GI II > Treatment of GI cancer > Flashcards

Treatment of GI cancer Flashcards

1
Q

First line treatment for gastroesophageal cancer

A

IV 5-FU or PO capecitabine

Fluorouracil based chemotherapy

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2
Q

Alternative treatments for gastroesophageal cancer

A

Cisplatin based regimens
Combined with either irinotecan or a taxane

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3
Q

Treatment for metastatic gastroesophageal cancer with overexpression of HER-2/neu receptor

A

Trastuzumab and cisplatin

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4
Q

Treatment of metastatic pancreatic cancer

A

Gemcitabine

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5
Q

Treatment of hepatocellular cancer

A

Sorafenib

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6
Q

Curative modality for localized colon cancer

A

Surgical removal/colectomy

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7
Q

Adjuvant chemotherapy for colon cancer for 6 mos after surgery

A

Oxaliplatin with 5-FU and leucovorin

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8
Q

Cytotoxic agent that is an analog of thymine and works by blocking DNA synthesis by inhibiting DNA polymerase and being incorporated into nascent DNA, causing chain termination.

A

Fluorouracil
Capecitabine (prodrug)

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9
Q

Uses of fluorouracil

A

Breast ca
Colorectal ca
Gastric ca
SCC of head and neck

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10
Q

Uses of capecitabine

A

Colorectal ca
Breast ca

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11
Q

Uses of oxaliplatin

A

Pancreatic ca
Colorectal ca
Gastroesophageal ca

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12
Q

Mechanism of irinotecan

A

Inhibits topoisomerase I

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13
Q

When is irinotecan used in colorectal ca?

A

Used in recurrence, or in progression after 5-FU therapy

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14
Q

Anti-VEGF monoclonal antibody used for treating metastatic colon ca

A

Bevacizumab

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15
Q

Adverse effects of bevacizumab

A

HTN
Increased thomboembolic events
Slowed wound healing
GI perforations
Proteinuria

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16
Q

Anti-EGFR monoclonal antibodies used in treating metastatic colorectal ca expressing KRAS or NRAS

A

Cetuximab
Panitumumab

17
Q

Adverse effects of cetuximab and panitumumab

A

Acneiform skin rash
Hypersensitivity infusion reaction
Hypomagnesemia

18
Q

Fusion protein that target VEGF-A, VEGF-B, and PIGF. Used for colorectal ca

A

Ziv-aflibercept

19
Q

Anti-VEGF-R2 antibody used for colorectal ca.

A

Ramucirumab

20
Q

Small molecule tyrosine kinase inhibitor used for colorectal ca

A

Regorafenib

21
Q

Symptoms of carcinoid syndrome

A

Flushing
Abd pain
Diarrhea
Bronchoconstriction
Carcinoid heart disease

22
Q

Cause of carcinoid syndrome

A

Release of vasoactive amines into the systemic ciruclation

23
Q

Only potential curative therapy for GI carcinoid tumors

A

Surgical resection

24
Q

Slow-growing GI tumors that originate in the neuroendocrine cells

A

Carcinoid tumors

25
Q

Short-acting somatostatin analog used in GI carcinoid tumors

A

Octreotide

26
Q

Long-acting somatostatin analog used in GI carcinoid tumors

A

Lanreotide

27
Q

Effect of somatostatin analogs in GI carcinoid tumors

A

Treat carcinoid syndrome by cAMP inhibition

28
Q

Drug used for inhibition of disease progression and symptom relief in GI carcinoid tumors

A

Interferon alpha

29
Q
A

GI II (31 decks)

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