Treatment of hepatitis

Question 1

Drugs used in for treating hepatic encephalopathy

Answer 1

Lactulose
Rifaximin
Metronidazole
Neomycin
Zinc sulfate
Osmotic laxatives

Question 2

Symptoms of lactulose overdose

Answer 2

Ileus
Severe diarrhea
Electrolyte disturbances
Hypovolemia

Question 3

Drug to avoid in acute HAV infection

Answer 3

Acetominophen

Question 4

Drug class of entacavir

Answer 4

Nucleoside and nucleotide reverse transcriptase inhibitor

Question 5

Guanosine nucleoside analog used to treat HBV infection

Answer 5

Entacavir

Question 6

Adenosine analogs used to treat HBV infection

Answer 6

Tenofovir
Adefovir

Question 7

Thymidine nuclease analog used to treat HBV infection

Answer 7

Telbivudine

Question 8

Cytidine analog used to treat HBV infection

Answer 8

Lamivudine

Question 9

Mechanism of nucleoside and nucleotide reverse transcriptase inhibitors

Answer 9

Inhibit formation of DNA copy of viral RNA

Question 10

Drug used for HBV, HCV, and refractory HPV that activates JAK-STAT signaling pathway and T cells

Answer 10

Interferon alfa

Question 11

Interferon alfa specific for HBV infection

Answer 11

INF-alfa-2b

Question 12

Interferon alfa specific for HCV infection

Answer 12

INF-alfa-2a
INF-alfa-2b
INF alfacon-1

Question 13

Dose-limiting toxicities of interferon alfa

Answer 13

Depression
Neurasthenia
Myelosuppression
Autoimmune disorders

Question 14

Contraindications of interferon alfa

Answer 14

Hepatic decompensation
Autoimmune disease
Hx of arrhythmia
Coadministration of didanosine or zidovine
Depression

Question 15

First line agents for HBV infection

Answer 15

Pegylated interferon alfa
Entecavir
Tenofovir

Question 16

Second line agents for HBV infection

Answer 16

Lamivudine
Telbivudine
Adefovir

Question 17

Drug class with potential to cure over 90% of pts with HCV infection

Answer 17

Direct-acting antivirals

Question 18

Class of DAA that acts by inhibiting serine protease and cleavage of HCV polyprotein

Answer 18

NS3/4A protease inhibitors

Question 19

Suffix of NS3/4A protease inhibitors

Answer 19

-previr

Question 20

Suffix of NS5A inhibitors

Answer 20

-asvir

Question 21

Class of DAA that acts by inhibiting activator of HCV RNA polymerase

Answer 21

NS5A inhibitors

Question 22

Suffix of NS5B polymerase inhibitors and NS5B non-nucleoside inhibitors

Answer 22

-buvir

Question 23

Classes of DAA that act by inhibiting HCV RNA-directed RNA polymerase

Answer 23

NS5B nucleoside polymerase inhibitors

NS5B non-nucleoside polymerase inhibitors

Question 24

Purpose of Ritonavir in combinations of DAAs for HCV infection

Answer 24

Inhibits metabolism of paritaprevir by CYP3A

Question 25

DAA active against all 6 HCV genotypes

Answer 25

Velpatasvir

Question 26

Drug interaction of velpatasvir

Answer 26

Amiodarone –> bradycardia

Question 27

Synthetic guanosine analog that can be used for HCV infection

Answer 27

Ribavirin

Question 28

Uses of Ribavirin

Answer 28

Chronic HCV
Severe RSV