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GI II > Treatment of hepatitis > Flashcards

Treatment of hepatitis Flashcards

1
Q

Drugs used in for treating hepatic encephalopathy

A

Lactulose
Rifaximin
Metronidazole
Neomycin
Zinc sulfate
Osmotic laxatives

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2
Q

Symptoms of lactulose overdose

A

Ileus
Severe diarrhea
Electrolyte disturbances
Hypovolemia

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3
Q

Drug to avoid in acute HAV infection

A

Acetominophen

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4
Q

Drug class of entacavir

A

Nucleoside and nucleotide reverse transcriptase inhibitor

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5
Q

Guanosine nucleoside analog used to treat HBV infection

A

Entacavir

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6
Q

Adenosine analogs used to treat HBV infection

A

Tenofovir
Adefovir

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7
Q

Thymidine nuclease analog used to treat HBV infection

A

Telbivudine

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8
Q

Cytidine analog used to treat HBV infection

A

Lamivudine

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9
Q

Mechanism of nucleoside and nucleotide reverse transcriptase inhibitors

A

Inhibit formation of DNA copy of viral RNA

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10
Q

Drug used for HBV, HCV, and refractory HPV that activates JAK-STAT signaling pathway and T cells

A

Interferon alfa

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11
Q

Interferon alfa specific for HBV infection

A

INF-alfa-2b

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12
Q

Interferon alfa specific for HCV infection

A

INF-alfa-2a
INF-alfa-2b
INF alfacon-1

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13
Q

Dose-limiting toxicities of interferon alfa

A

Depression
Neurasthenia
Myelosuppression
Autoimmune disorders

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14
Q

Contraindications of interferon alfa

A

Hepatic decompensation
Autoimmune disease
Hx of arrhythmia
Coadministration of didanosine or zidovine
Depression

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15
Q

First line agents for HBV infection

A

Pegylated interferon alfa
Entecavir
Tenofovir

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16
Q

Second line agents for HBV infection

A

Lamivudine
Telbivudine
Adefovir

17
Q

Drug class with potential to cure over 90% of pts with HCV infection

A

Direct-acting antivirals

18
Q

Class of DAA that acts by inhibiting serine protease and cleavage of HCV polyprotein

A

NS3/4A protease inhibitors

19
Q

Suffix of NS3/4A protease inhibitors

A

-previr

20
Q

Suffix of NS5A inhibitors

A

-asvir

21
Q

Class of DAA that acts by inhibiting activator of HCV RNA polymerase

A

NS5A inhibitors

22
Q

Suffix of NS5B polymerase inhibitors and NS5B non-nucleoside inhibitors

A

-buvir

23
Q

Classes of DAA that act by inhibiting HCV RNA-directed RNA polymerase

A

NS5B nucleoside polymerase inhibitors

NS5B non-nucleoside polymerase inhibitors

24
Q

Purpose of Ritonavir in combinations of DAAs for HCV infection

A

Inhibits metabolism of paritaprevir by CYP3A

25
Q

DAA active against all 6 HCV genotypes

A

Velpatasvir

26
Q

Drug interaction of velpatasvir

A

Amiodarone –> bradycardia

27
Q

Synthetic guanosine analog that can be used for HCV infection

A

Ribavirin

28
Q

Uses of Ribavirin

A

Chronic HCV
Severe RSV

GI II (31 decks)

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