Treatment of IBD

Question 1

Step 1 treatment for Ulcerative Colitis

Answer 1

topical aminosalicylate / add oral aminosalicylate

Question 2

If step 1 treatment for ulcerative colitis is contraindicated, what should be used?

Answer 2

topical corticosteroid

oral prednisolone

Question 3

What is Step 1 treatment for Ulcerative Colitis used for?

Answer 3

proctitis

proctosigmoiditis

Question 4

Step 2 treatment for Ulcerative Colitis

Answer 4

add oral prednisolone

to aminosalicylate therapy

Question 5

Treatment for moderate to severely active Ulcerative Colitis

Answer 5

infliximab

adalimumab

Question 6

What is involved in monotherapy of Crohn’s Disease

Answer 6

prednisolone
methylprednisolone
IV hydrocortisone

Question 7

What treatment can be used if Crohn’s Disease isn’t severe?

Answer 7

5-ASA treatment

Question 8

Add on treatments for Crohn’s Disease

Answer 8

Azathioprine
Mercaptopurine
Methotrexate

Question 9

What is sulfasalazine composed of?

Answer 9

sulfenamide sulfapyridine

5-amino-salicylic acid

Question 10

How does sulfasalazine reduce inflammation?

Answer 10

scavenging free radicals
inhibition of Prostaglandin and Leukotriene production
decreasing neutrophil chemotaxis

Question 11

Side effects of sulfasalazine

Answer 11

diarrhoea
salicylate sensitivity
interstitial nephritis

Question 12

What is mesalazine?

Answer 12

5-ASA

Question 13

What is olsalazine?

Answer 13

5-ASA dimer

Question 14

What is balsalazide?

Answer 14

pro-drug that releases 5-ASA