Respiratory and Inflammatory Drugs

Question 1

Immediate Phase Asthma Drug Types

Answer 1

B2-adrenoceptor agonists
CysLT-receptor antagonists
Theophylline

Question 2

Chlorphenamine
Diphenhydramine

drowsiness
difficulty urinating
constipation

Answer 2

First gen. antihistamines and side effects

Question 3

Which receptors does adrenaline target?

Answer 3

alpha
beta1
beta2

Question 4

H1 antihistamines can be…

Answer 4

antagonist

inverse agonist

Question 5

Late Phase Pharmacological targets

Answer 5

corticosteroids
5-lipoxygenase inhibitor
leukotriene antagonists

Question 6

Salmeterol

Formoterol

Answer 6

Longer-acting beta2 agonists

Question 7

Salbutamol

Terbutaline

Answer 7

Short-acting beta2 agonists

Question 8

inhibits phospholipase A2 -> production of lipocortin
inhibits NFkB directly and indirectly
inhibits Toll-like receptor signalling
inhibits recruitment and activation of leukocytes

Answer 8

Glucocorticoid mechanisms of inhibition

Question 9

Cetirizine

Loratadine

Answer 9

Second gen. antihistamine examples

Question 10

Noradrenaline
Vasopressin
Metaraminol

Answer 10

Examples of vasopressors

Question 11

Prednisolone

Hydrocortisone

Answer 11

Oral Corticosteroids

Question 12

Reduced transcription and formation of pro-inflammatory mediators, cytokines, Th2 cytokines
Reduced eosinophil activation
Reduced IgE production
Reduced production of leukotrienes and PAF
Inhibition of the induction of the cyclooxygenase pathway

Answer 12

Inhaled Corticosteroid Mechanism of action (5)

Question 13

Beclometasone

Budesonide

Answer 13

Inhaled Corticosteroid examples

Question 14

M3 receptor antagonist properties
Ipratropium
Tiotropium

Answer 14

Antimuscarin drugs

Question 15

phosphodiesterase inhibitors
prevent cAMP breakdown

Theophylline

Answer 15

Methylxanthines mechanism of action & example

Question 16

block cysteinyl LT1 receptor

Montelukast
Zafirlukast

Answer 16

Leukotriene receptor antagonist mechanism & examples