Immune Cells and Responses

Question 1

How does the spleen respond to infection?

Answer 1

releases monocytes

differentiate into macrophages

Question 2

Main functions of macrophage (2)

Answer 2

produce cytokines

activation of adaptive immune cells

Question 3

phagocytosis of blood-borne pathogens
production of cytokines
differentiate into macrophages or dendritic cells
antigen presentation via MHC II complexes

Answer 3

Functions of monocytes

Question 4

Which white blood cells are derived from myeloid progenitors?

Answer 4

Mast Cell
Myeloblast
Basophil
Neutrophil
Eosinophil
Monocyte
Macrophage
Dendritic cell

Question 5

What are natural killer cells regulated by?

Answer 5

MHC-I mediated cytolytic granule mediated cell apoptosis

antibody-dependent cell-mediated cytotoxicity

Question 6

Which wbc’s are derived from lymphoid progenitors?

Answer 6

B Cell
T Cell
natural Killer Cell

Question 7

Secondary Lymphoid Organs and their function

Answer 7

lymph nodes - filters lymph

spleen - filters blood, monocyte storage

Question 8

Primary Lymphoid Organs and their function

Answer 8

thymus - t cell maturation

bone marrow - wbc generation

Question 9

Function of CD4+ Helper T Cells

Answer 9

secrete cytokines to coordinate immune responses

Question 10

Function of CD4+ Regulatory T Cells

Answer 10

actively suppress activation of the immune system

Question 11

Main function of dendritic cells

Answer 11

antigen presentation via MHC II complexes

Question 12

Artificial Passive Immunity

Answer 12

antibodies from immune individuals

Question 13

Artificial Active Immunity

Answer 13

antigens enter via vaccination

Question 14

Natural Passive Immunity

Answer 14

antibodies acquired from mother to fetus

Question 15

Natural Active Immunity

Answer 15

antibodies acquired from infection

Question 16

degranulation during inflammatory responses

stain blue-purple

Answer 16

Function of basophils and stain colour

Question 17

Function of Mast Cells

Answer 17

sentinel cell
degranulates during inflammatory response
secretes histamine

Question 18

phagocytosis of larger cells
fight parasites
degranulation during allergic disease

stain pink

Answer 18

Eosinophil functions and stain colour

Question 19

phagocytosis and destruction of bacteria via oxidative burst

stain light-pink / reddish purple

Answer 19

Neutrophil function and stain colour

Question 20

CD4+ T cells recognise ___ antigens presented on ___ complexes

Answer 20

foreign

MHC II

Question 21

CD8+ T cells recognise ___ antigens presented on ___ complexes

Answer 21

self

MHC I

Question 22

4 types of T lymphocytes

Answer 22

Helper
Regulatory
Cytotoxic
Memory

Question 23

Main function of CD8+ T cells

Answer 23

induce apoptosis in cancer cells/infected cells