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Year 1 Medicine > Immune Cells and Responses > Flashcards

Immune Cells and Responses Flashcards

1
Q

How does the spleen respond to infection?

A

releases monocytes

differentiate into macrophages

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2
Q

Main functions of macrophage (2)

A

produce cytokines

activation of adaptive immune cells

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3
Q

phagocytosis of blood-borne pathogens
production of cytokines
differentiate into macrophages or dendritic cells
antigen presentation via MHC II complexes

A

Functions of monocytes

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4
Q

Which white blood cells are derived from myeloid progenitors?

A 
Mast Cell
Myeloblast
Basophil
Neutrophil
Eosinophil
Monocyte
Macrophage
Dendritic cell
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5
Q

What are natural killer cells regulated by?

A

MHC-I mediated cytolytic granule mediated cell apoptosis

antibody-dependent cell-mediated cytotoxicity

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6
Q

Which wbc’s are derived from lymphoid progenitors?

A

B Cell
T Cell
natural Killer Cell

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7
Q

Secondary Lymphoid Organs and their function

A

lymph nodes - filters lymph

spleen - filters blood, monocyte storage

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8
Q

Primary Lymphoid Organs and their function

A

thymus - t cell maturation

bone marrow - wbc generation

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9
Q

Function of CD4+ Helper T Cells

A

secrete cytokines to coordinate immune responses

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10
Q

Function of CD4+ Regulatory T Cells

A

actively suppress activation of the immune system

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11
Q

Main function of dendritic cells

A

antigen presentation via MHC II complexes

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12
Q

Artificial Passive Immunity

A

antibodies from immune individuals

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13
Q

Artificial Active Immunity

A

antigens enter via vaccination

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14
Q

Natural Passive Immunity

A

antibodies acquired from mother to fetus

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15
Q

Natural Active Immunity

A

antibodies acquired from infection

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16
Q

degranulation during inflammatory responses

stain blue-purple

A

Function of basophils and stain colour

17
Q

Function of Mast Cells

A

sentinel cell
degranulates during inflammatory response
secretes histamine

18
Q

phagocytosis of larger cells
fight parasites
degranulation during allergic disease

stain pink

A

Eosinophil functions and stain colour

19
Q

phagocytosis and destruction of bacteria via oxidative burst

stain light-pink / reddish purple

A

Neutrophil function and stain colour

20
Q

CD4+ T cells recognise ___ antigens presented on ___ complexes

A

foreign

MHC II

21
Q

CD8+ T cells recognise ___ antigens presented on ___ complexes

A

self

MHC I

22
Q

4 types of T lymphocytes

A

Helper
Regulatory
Cytotoxic
Memory

23
Q

Main function of CD8+ T cells

A

induce apoptosis in cancer cells/infected cells

Year 1 Medicine (25 decks)

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