Physiology of Hepatobiliary system Flashcards
1
Q
What are bile acids synthesised from?
A
cholesterol
2
Q
Primary bile acids
A
cholic acid
chenodeoxycholic acid
3
Q
Main transporter for bile salts
A
BSEP transporter
4
Q
What causes a decrease in transcription of cholesterol 7a-hydroxylase gene?
A
accumulation of bile acids
5
Q
Function of cholesterol 7a-hydroxylase gene
A
enzyme that forms rate limiting step in synthesis of bile from cholesterol
6
Q
What are bile acids detected by?
A
FXR (farnesoid X receptor)
7
Q
What causes contraction of gallbladder and biliary tree
A
Cholecystokinin
8
Q
What stimulates duct cells to secrete bicarbonate and water
A
Secretin
9
Q
What stimulates the gallbladder to contract and release bile?
A
Vagus nerve
10
Q
Main site of bile acid reabsorption
A
terminal ileum
