Treatment of Endocrine disorders

Question 1

signs for a thyrotoxic crisis (4)

Answer 1

restlessness
tachycardia
tremor
hyperthermia

Question 2

effects of iodine/iodine preps on the thyroid gland? (3)

Answer 2

• Decrease the vascularity of the thyroid gland
• increase the amount of bound (inactive hormone)
• inhibits the release of thyroid hormone into circulation

Question 3

side effects of iodine/iodide preps

Answer 3

Derm and GI plus mucous membrane ulceration and metallic taste

Question 4

Most common and preferred treatment for hyperthyroidism – over age 30

Answer 4

Iodine-131 (Radioactive Iodine)

Question 5

what does Radioactive Iodine-131 emmit?

Answer 5

gamma rays and beta rays

Question 6

half life of radioactive iodine

Answer 6

8 days

Question 7

radioactive iodine - 131 as treatment for hyperthyroidism will ultimately lead to what?

Answer 7

hypothyroidism

Question 8

what should be monitored in patients taking radioactive iodine 131?

Answer 8

radiation sickness (hematemesis, epistaxis, intense nausea, vomiting)

Question 9

actions of growth hormone (3)

Answer 9

Promotes growth
Promotes protein synthesis
Carbohydrate metabolism

Question 10

what does a deficiency of growth hormone result in?

Answer 10

short stature

Question 11

what does a excess of growth hormone in childhood result in?

Answer 11

gigantism

Question 12

what does a excess of growth hormone in adults result in?

Answer 12

acromegaly

Question 13

what is somatropin used for

Answer 13

as a synthetic growth hormone

Question 14

adverse effects of somatropin (5)

Answer 14

Hyperglycemia
Hypercalciuria and renal calculi
Hypothyroidism
Antibody formation to GH
Interaction with glucocorticoids

Question 15

preferred drug for diabetes insipidus

Answer 15

desmopressin

Question 16

what is vasopressin used as

Answer 16

a replacement for ADH

Question 17

what is adrenal hormone excess known as?

Answer 17

Cushing’s syndrome

Question 18

corticosteroid prototype

Answer 18

hydrocortisone

Question 19

adverse effects of short-term gulcocorticoid therapy (4)

Answer 19

mild CNS + complaints
increased infections
poor wound healing
hyperglycemia

Question 20

adverse effects of long-term gulcocorticoid therapy (5)

Answer 20

Cushingoid characteristics
Adrenal suppression
Osteopenia/Osteoporosis
Fluid retention/Edema
Electrolyte imbalance

Question 21

describe fludrocortisone

Answer 21

Potent mineralocorticoid and has some glucocorticoid effects.

Question 22

use for fludrocortisone

Answer 22

Mineralocorticoid replacement therapy in adrenocortical deficiency (Addison’s disease)

Question 23

potential adverse effects of fludrocortisone (5)

Answer 23

Edema
Hypertension
CHF
Cardiomegaly
Hypokalemic alkalosis

Question 24

when does levothyroxine start working?

Answer 24

within a few weeks

Question 25

what is the effect of propanol on when treating grave’s disease?

Answer 25

decrease tremors and reduce heart beat

Question 26

what does the thyroid preparation liothyronine consist of?

Answer 26

synthetic thyroid hormone T3

Question 27

what does the thyroid preparation liotrix consist of?

Answer 27

Synthetic thyroid hormone T3-T4 combined

Question 28

how does the thyroid behave in grave’s disease?

Answer 28

excessive thyroid hormone secretion