Toxic responses of the immune system

Question 1

Which of the following cells or substances is NOT part of the innate immune system?

a. Lysozyme
b. Monocytes
c. complement
d. antibodies
e. neutrophils

Answer 1

d. antibodies

Question 2

Myeloid precursors stem cells are respon9sible for the formation of all of the following EXCEPT:

a. platelets
b. lymphocytes
c. basophils
d. erythrocytes
e. monocytes

Answer 2

b. lymphocytes

Question 3

When an Rh- mother is exposed to the blood of an RT+ baby during childbirth, the mother will make antibodies against the Rh factor, which can lead to the mother attacking the next Rh+ fetus. This is all possible because of which antibody’s ability to cross the placenta?

a. IgM
b. IgE
c. IgG
d. IgA
e. IgD

Answer 3

c. IgG

Question 4

Which of the following statements is FALSE regarding important cytokine function in regulating the immune system?

a. IL-1 induces inflammation and fever.
b. IL-3 is the primary T-celll growth factor.
c. IL-4 induces B-cell differentiation and isotype switching
d. Transforming growth factor-beta (TGF-beta) enhances monocyte/macrophage chemotaxis
e. Interferon gamma (IFN-gamma) activates macrophages.

Answer 4

c. IL-4 induces B-cell differentiation and isotype switching

Question 5

Which of the following is NOT a step performed during an enzyme-linked immunosorbent assay (ELISA)?

a. A chromogen is added and color is detected
b. The antigen of interest is fixed to a microtiter plate
c. Radioactively labeled cells are added to the solution
d. Enzyme-tagged secondary antibodies are added.
e. Test sera are added

Answer 5

c. Radioactively labeled cells are added to the solution

Question 6

The delayed hypersensitivity response (DHR) test does NOT:

a. evaluate memory T-cells’ ability to recognize a foreign antigen
b. evaluate memory T-cells’ ability to secrete cytokines
c. evaluate memory T-cells’ ability to proliferate
d. evaluate memory T-cells’ ability to lyse foreign target cells
e. Evaluate memory T-cells’ ability to migrate to the site of foreign antigen.

Answer 6

d. evaluate memory T-cells’ ability to lyse foreign target cells

Question 7

The number of alveolar macrophages in smokers is greatly increased relative to non-smokers. What is a characteristic of the alveolar macrophages found in smokers?

a. They are in an inactive state
b. They are far larger than normal.
c. They have increased phagocytic activity.
d. They are incapable of producing cytokines
e. They have decreased bactericidal activity.

Answer 7

e. They have decreased bactericidal activity.

Question 8

Which of the following is NOT characteristic of a type I hypersensitivity reaction?

a. It is mediated by IgE
b. It involves immune complex deposition in peripheral tissues
c. It involves mast-cell degranulation
d. Anaphylaxis is an acute , systemic, and very severe type I hypersensitivity reaction
e. It is usually mediated by preformed histamine, prostaglandins and leukotrienes

Answer 8

b. It involves immune complex deposition in peripheral tissues

Question 9

Which of the following types of hypersensitivity is NOT mediated by antibodies?

a. type I
b. type II
c. type III
d. type IV
e. type V.

Answer 9

d. type IV

Question 10

Which of the following is NOT a common mechanism of autoimmune disorders?

a. subjection to positive selection in the thymus
b. anergic T cells become activated.
c. interference with normal immunoregulation by CD8+ suppressor T cells
d. lack of subjection to negative selection in the thymus.
e. decreased self-tolerance

Answer 10

a. subjection to positive selection in the thymus