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Pharm > Topical anti-fungals > Flashcards

Topical anti-fungals Flashcards

1
Q

Class/Indication: Terbinafine

A

Allylamine/benzylamine

Tinea capitis, Tinea pedis, Tinea corporis, dermatophytes

less activity against Candida

Terbinafine: Terb is in a fight with Tamaya and Darren, he’s fine with Cynthia but not great. The B in his name is for benzy

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2
Q

Class/Indication: Clotrimazole, ketoconazole, miconazole, econazole, sertaconazole, oxiconazole, sulconazole

A

Imidazole

Dermatophytes and yeasts

Azoles: Go to the Azores where you can tan your dermis and eat yeasty bread

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3
Q

Class/Indication: Nystatin

A

Polyene

Antifungal, candida, not effective against dermatophytes

Nystatin: Nastya dances on the Pole, she Avoided Fungus Candy but not the darn dermatophytes

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4
Q

Indication: Tolnaftate

A

Superficial fungal infections

Superman paid the Toll after he ate mushrooms

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5
Q

Class/Indication: Naftifine

A

Allylamine/benzylamine

Tinea capitis, Tinea pedis, Tinea corporis

Good for Candida

Naftifine: Naft took a raft to Ally’s house, they drank Chamomile Tea because she’s so boring .

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6
Q

Class/Indication: Butenafine

A

Allylamine/benzylamine

Tinea capitis, Tinea pedis, Tinea corporis

less active against Candida

Ally and Ben took a train to Butan, they found a Tin boat but couldnt paddle to Canada

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7
Q

Extra indication for Clotrimazole

A

is active against a wide variety of fungi, yeasts and dermatophytes

Clotrimazole: Chloe cooks with lots of mushrooms, and dont phy-get the yeast

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8
Q

Extra indication for Miconazole

A

inhibits the growth of common dermatophytes and the active organisms in tinea versicolor

Miconazole: My common dermatophytes vary in color

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9
Q

Extra indication for Ketoconazole

A

is broad-spectrum and has activity against dermatophytes and some yeast organisms

may cause allergic type reactions ranging from asthmatic episodes to anaphylactic symptoms

Ketoconazole: Keto diet helps shed those derms and yeasts, but it can make you sort of sick

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10
Q

Extra indication for Econazole and oxiconazole

A

is broad-spectrum and has activity against dermatophytes and some yeast organisms

For a good Economy you need a broad portfolio and a lot of phyte, and yeast need oxygen to rise

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11
Q

Extra indication for Sertaconazole

A

only indicated for interdigit tinea pedis treatment

Sir, that’s my finger

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12
Q

Indication for Ciclopirox olamine

A

Tinea

Good for Candida

Comes as nail lacquer to kill onychomycosis

Cyclone: Its a tinea twister, Dorothy painted her nails after she killed Ony and Can (John).

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13
Q

General info about topical antifungals: Poor absorption from

A

intact skin

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14
Q

General info about topical antifungals: Small amounts absorbed are metabolized in the liver and excreted in

A

bile

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15
Q

Ciclopirox topical nail lacquer should not be used in ___ with onychomycosis

A

immunocompromised or diabetic patients

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16
Q

Drug Interactions: Clotrimazole intravaginal

A

May inactivate spermicides

17
Q

Drug Interactions: Corticosteroids + econazole

A

equal concentrations cause inhibition of antifungals

18
Q

Azoles: miconazole and clotrimazole frequency

A

BID

19
Q

Nystatin cream, ointment or powder frequency

A

2-3 times daily

20
Q

Thrush- treatment should last

A

48 hrs post symptom resolution

21
Q

Thrush treatment: Nystatin swish and swallow frequency

A

QID

22
Q

Thrush treatment: Clotrimazole troches frequency

A

five times daily x 14 days

23
Q

Cutaneous Candida infections: If nystatin, miconazole, and clotrimazole dont work, try

A

Other azoles

Oral fluconazole

24
Q

T. Capitis- ringworm of the scalp. Treatment

A

Griseofulvin PO and twice weekly shampooing with sporicidal shampoo; selenium sulfide or ketoconazole

25
Q

____ must be taken with a high fat meal to increase absorption

A

Griseofulvin

26
Q

How do you take Griseofulvin

A

Griseofulvin must be taken with a high fat meal to increase absorption

27
Q

T. Capitis- ringworm of the scalp is treated with Griseofulvin for how long

A

2 to 4 months

28
Q

T. Capitis- ringworm of the scalp: If Griseofulvin does not work use PO t____, f____, i____

A

PO terbinafine, fluconazole and itraconazole

29
Q

What is T. Corporis

A

superficial ringworm fungal infection of the skin

30
Q

What is T. Cruris

A

jock itch;superficial fungal infection of the groin, upper thighs and intertriginous folds

Jocks on the crew team get it

31
Q

T. Cruris- jock itch: treatment:

A

topical antifungal cream- miconazole, tolnaftate, or clotrimazole

If your balls itch, Maybe Tonight Clean down there

32
Q

what is T. Pedis

A

athletes foot

pedis=foot

33
Q

T. Pedis treatment

A

topical antifungal cream- miconazole, tolnaftate, or clotrimazole for 4 weeks

If your feet itch, Maybe Think about Cleaning them

34
Q

what is T. Versicolor

A

superficial fungal infection of the skin caused by yeasts.

35
Q

T. Versicolor treatment

A

Topical selenium sulfide shampoo or topical antifungal x 1 week
Topical azoles: miconazole, clotrimazole, and econazole x 2-4 weeks

36
Q

what is T. Unguium aka Onychomycosis

A

fungal infection of the nail

37
Q

T. Unguium aka Onychomycosis 1st line treatment

A

Itraconazole , terbinafine

IT doesn’t make sense

38
Q

T. Unguium aka Onychomycosis 2nd line treatment

A

griseofulvin- monitor renal, liver, and CBC

Griselle went number 2, everyone threw up their kidney beans, liver pie, and blood pie

39
Q

T. Unguium aka Onychomycosis alternative treatment if 2nd line doesn’t work

A

ciclopirox nail lacquer (Indicated in superficial white onychomycosis with less than 50% of the nail surface affected, when four or less nails are infected)

Pharm (23 decks)

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