MRSA Flashcards
Often it first appears to be
a spider bite or abscess
Staph is commonly carried, ___ of people are colonized
25 to 30%
MRSA occurs most commonly in
hospitalized people with weakened immune system
MRSA is considered community-associated if the person
hasn’t been hospitalized in the past year or has not had an invasive procedure
If you hear ___, think MRSA
pus
can cause infection that look like __ or __
pimple or boil
___ monitoring important for persons returning from hospitals
skin
More serious infections may cause ___, ___ infections, or ___ wound infections
pneumonia, bloodstream infections, surgical wound infections
athletes, army, prisoners, MSM
people at risk for MRSA
factors for getting MRSA: close
skin to skin contact
factors for getting MRSA: ___ living conditions
crowded
factors for getting MRSA: __ to the skin
cuts
factors for getting MRSA: __ items
contaminated
factors for getting MRSA: poor ___
hygiene
Prevention: to prevent cracking
use lotion
the 5 “C”s
clean compromised contact contamination crowding
community MRSA medication list
Did Linda Try Calling? Doxycycline/minocycline Linezolid TMP-SMX Clindamycin
Healthcare MRSA medication list
Caroline didn't Venmo Lenny the Dollas? Ceftaroline Daptomycin Vancomycin Linezolid Dalbavancin
Vancomycin: has Time dependent killing, which means
Higher antimicrobial concentration does not increase the rate of microorganism killed
Vancomycin: ___ ___ are preferred for MSSA
Beta lactams
Vancomycin: give PO for
c dif
Vancomycin: give IV for
systemic infections
Vancomycin: Concomitant administration with ____ may increase occurrences of renal toxicities
piperacillin/tazobactam
Vancomycin: red man syndrome
a histamine release. Pretreatment with antihistamines, or prolonging infusion should alleviate this reaction. In general, 1g should be administered over 1 hour.
Vancomycin: Monitoring: Baseline serum creatinine
Changes of 0.3mg/dL require adjustment to dose/frequency
Vancomycin: Monitoring: If stable,
weekly monitoring is appropriate
Linezolid Its unique binding site results in
no cross-resistance with other drug classes
Use IV only if
they can’t take PO (IV and PO dosing is the same, such good bioavailability that you don’t need IV)
Linezolid: ADR: t____
Thrombocytopenia
Linezolid: ADR: ____and ___ neuropathy
Optic and peripheral neuropathy
Linezolid: drug to drug interaction
can cause serotonin syndrome with SSRIs.
Linezolid: drug to drug interaction: SSRIs should not be taken within
2 weeks (if fluoxetine its 5 weeks)
Linezolid: drug to drug interaction: If you can’t wait for the 2 week wash out period before starting linezolid,
d/c the SSRI but monitor them for 2 weeks
Linezolid: drug to drug interaction: in addition to SSRIs avoid
all antidepressants and food with tyramine
Daptomycin: Spectrum of activity is similar to vancomycin, but may provide
more rapid clearance of bacteria
what is Daptomycin dosing based on
Generally use actual body weight
Daptomycin dosage adjustments necessary in ___ ____
renal insufficiency
Adverse effects of Daptomycin are m___ and r___
Myopathy and rhabdomyolysis
Daptomycin: Monitor ___ levels at baseline and weekly
creatine phosphokinase (CPK)
Daptomycin: drug to drug interaction
statins (May increase the risk of myopathy)
Daptomycin: Limitation of use
Do not use for pneumonia (messes up surfactant)
Only cephalosporin with activity against MRSA
Ceftaroline fosamil
Dalbavancin: Not active against v___ ____ ___ (__)
vancomycin resistant Enterococcus (VRE)
Dalbavancin: has a long
half life
Dalbavancin: Use caution in patients with reported ___ hypersensitivities
glycopeptide
Dalbavancin: ___ may result in “Red-man” syndrome (similar to vancomycin
Infusion times faster than the recommended 30 minutes
