MRSA

Question 1

Often it first appears to be

Answer 1

a spider bite or abscess

Question 2

Staph is commonly carried, ___ of people are colonized

Answer 2

25 to 30%

Question 3

MRSA occurs most commonly in

Answer 3

hospitalized people with weakened immune system

Question 4

MRSA is considered community-associated if the person

Answer 4

hasn’t been hospitalized in the past year or has not had an invasive procedure

Question 5

If you hear ___, think MRSA

Answer 5

pus

Question 6

can cause infection that look like __ or __

Answer 6

pimple or boil

Question 7

___ monitoring important for persons returning from hospitals

Answer 7

skin

Question 8

More serious infections may cause ___, ___ infections, or ___ wound infections

Answer 8

pneumonia, bloodstream infections, surgical wound infections

Question 9

athletes, army, prisoners, MSM

Answer 9

people at risk for MRSA

Question 10

factors for getting MRSA: close

Answer 10

skin to skin contact

Question 11

factors for getting MRSA: ___ living conditions

Answer 11

crowded

Question 12

factors for getting MRSA: __ to the skin

Answer 12

cuts

Question 13

factors for getting MRSA: __ items

Answer 13

contaminated

Question 14

factors for getting MRSA: poor ___

Answer 14

hygiene

Question 15

Prevention: to prevent cracking

Answer 15

use lotion

Question 16

the 5 “C”s

Answer 16

clean
compromised 
contact
contamination 
crowding

Question 17

community MRSA medication list

Answer 17

Did Linda Try Calling?
Doxycycline/minocycline
Linezolid
TMP-SMX
Clindamycin

Question 18

Healthcare MRSA medication list

Answer 18

Caroline didn't Venmo Lenny the Dollas?
Ceftaroline
Daptomycin
Vancomycin
Linezolid
Dalbavancin

Question 19

Vancomycin: has Time dependent killing, which means

Answer 19

Higher antimicrobial concentration does not increase the rate of microorganism killed

Question 20

Vancomycin: ___ ___ are preferred for MSSA

Answer 20

Beta lactams

Question 21

Vancomycin: give PO for

Answer 21

c dif

Question 22

Vancomycin: give IV for

Answer 22

systemic infections

Question 23

Vancomycin: Concomitant administration with ____ may increase occurrences of renal toxicities

Answer 23

piperacillin/tazobactam

Question 24

Vancomycin: red man syndrome

Answer 24

a histamine release. Pretreatment with antihistamines, or prolonging infusion should alleviate this reaction. In general, 1g should be administered over 1 hour.

Question 25

Vancomycin: Monitoring: Baseline serum creatinine

Answer 25

Changes of 0.3mg/dL require adjustment to dose/frequency

Question 26

Vancomycin: Monitoring: If stable,

Answer 26

weekly monitoring is appropriate

Question 27

Linezolid Its unique binding site results in

Answer 27

no cross-resistance with other drug classes

Question 28

Use IV only if

Answer 28

they can't take PO (IV and PO dosing is the same, such good bioavailability that you don't need IV)

Question 29

Linezolid: ADR: t____

Answer 29

Thrombocytopenia

Question 30

Linezolid: ADR: ____and ___ neuropathy

Answer 30

Optic and peripheral neuropathy

Question 31

Linezolid: drug to drug interaction

Answer 31

can cause serotonin syndrome with SSRIs.

Question 32

Linezolid: drug to drug interaction: SSRIs should not be taken within

Answer 32

2 weeks (if fluoxetine its 5 weeks)

Question 33

Linezolid: drug to drug interaction: If you can't wait for the 2 week wash out period before starting linezolid,

Answer 33

d/c the SSRI but monitor them for 2 weeks

Question 34

Linezolid: drug to drug interaction: in addition to SSRIs avoid

Answer 34

all antidepressants and food with tyramine

Question 35

Daptomycin: Spectrum of activity is similar to vancomycin, but may provide

Answer 35

more rapid clearance of bacteria

Question 36

what is Daptomycin dosing based on

Answer 36

Generally use actual body weight

Question 37

Daptomycin dosage adjustments necessary in ___ ____

Answer 37

renal insufficiency

Question 38

Adverse effects of Daptomycin are m___ and r___

Answer 38

Myopathy and rhabdomyolysis

Question 39

Daptomycin: Monitor ___ levels at baseline and weekly

Answer 39

creatine phosphokinase (CPK)

Question 40

Daptomycin: drug to drug interaction

Answer 40

statins (May increase the risk of myopathy)

Question 41

Daptomycin: Limitation of use

Answer 41

Do not use for pneumonia (messes up surfactant)

Question 42

Only cephalosporin with activity against MRSA

Answer 42

Ceftaroline fosamil

Question 43

Dalbavancin: Not active against v___ ____ ___ (__)

Answer 43

vancomycin resistant Enterococcus (VRE)

Question 44

Dalbavancin: has a long

Answer 44

half life

Question 45

Dalbavancin: Use caution in patients with reported ___ hypersensitivities

Answer 45

glycopeptide

Question 46

Dalbavancin: ___ may result in “Red-man” syndrome (similar to vancomycin

Answer 46

Infusion times faster than the recommended 30 minutes