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Pharm > MRSA > Flashcards

MRSA Flashcards

1
Q

Often it first appears to be

A

a spider bite or abscess

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2
Q

Staph is commonly carried, ___ of people are colonized

A

25 to 30%

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3
Q

MRSA occurs most commonly in

A

hospitalized people with weakened immune system

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4
Q

MRSA is considered community-associated if the person

A

hasn’t been hospitalized in the past year or has not had an invasive procedure

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5
Q

If you hear ___, think MRSA

A

pus

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6
Q

can cause infection that look like __ or __

A

pimple or boil

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7
Q

___ monitoring important for persons returning from hospitals

A

skin

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8
Q

More serious infections may cause ___, ___ infections, or ___ wound infections

A

pneumonia, bloodstream infections, surgical wound infections

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9
Q

athletes, army, prisoners, MSM

A

people at risk for MRSA

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10
Q

factors for getting MRSA: close

A

skin to skin contact

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11
Q

factors for getting MRSA: ___ living conditions

A

crowded

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12
Q

factors for getting MRSA: __ to the skin

A

cuts

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13
Q

factors for getting MRSA: __ items

A

contaminated

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14
Q

factors for getting MRSA: poor ___

A

hygiene

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15
Q

Prevention: to prevent cracking

A

use lotion

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16
Q

the 5 “C”s

A 
clean
compromised 
contact
contamination 
crowding
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17
Q

community MRSA medication list

A 
Did Linda Try Calling?
Doxycycline/minocycline
Linezolid
TMP-SMX
Clindamycin
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18
Q

Healthcare MRSA medication list

A 
Caroline didn't Venmo Lenny the Dollas?
Ceftaroline
Daptomycin
Vancomycin
Linezolid
Dalbavancin
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19
Q

Vancomycin: has Time dependent killing, which means

A

Higher antimicrobial concentration does not increase the rate of microorganism killed

20
Q

Vancomycin: ___ ___ are preferred for MSSA

A

Beta lactams

21
Q

Vancomycin: give PO for

A

c dif

22
Q

Vancomycin: give IV for

A

systemic infections

23
Q

Vancomycin: Concomitant administration with ____ may increase occurrences of renal toxicities

A

piperacillin/tazobactam

24
Q

Vancomycin: red man syndrome

A

a histamine release. Pretreatment with antihistamines, or prolonging infusion should alleviate this reaction. In general, 1g should be administered over 1 hour.

25
Q

Vancomycin: Monitoring: Baseline serum creatinine

A

Changes of 0.3mg/dL require adjustment to dose/frequency

26
Q

Vancomycin: Monitoring: If stable,

A

weekly monitoring is appropriate

27
Q

Linezolid Its unique binding site results in

A

no cross-resistance with other drug classes

28
Q

Use IV only if

A

they can’t take PO (IV and PO dosing is the same, such good bioavailability that you don’t need IV)

29
Q

Linezolid: ADR: t____

A

Thrombocytopenia

30
Q

Linezolid: ADR: ____and ___ neuropathy

A

Optic and peripheral neuropathy

31
Q

Linezolid: drug to drug interaction

A

can cause serotonin syndrome with SSRIs.

32
Q

Linezolid: drug to drug interaction: SSRIs should not be taken within

A

2 weeks (if fluoxetine its 5 weeks)

33
Q

Linezolid: drug to drug interaction: If you can’t wait for the 2 week wash out period before starting linezolid,

A

d/c the SSRI but monitor them for 2 weeks

34
Q

Linezolid: drug to drug interaction: in addition to SSRIs avoid

A

all antidepressants and food with tyramine

35
Q

Daptomycin: Spectrum of activity is similar to vancomycin, but may provide

A

more rapid clearance of bacteria

36
Q

what is Daptomycin dosing based on

A

Generally use actual body weight

37
Q

Daptomycin dosage adjustments necessary in ___ ____

A

renal insufficiency

38
Q

Adverse effects of Daptomycin are m___ and r___

A

Myopathy and rhabdomyolysis

39
Q

Daptomycin: Monitor ___ levels at baseline and weekly

A

creatine phosphokinase (CPK)

40
Q

Daptomycin: drug to drug interaction

A

statins (May increase the risk of myopathy)

41
Q

Daptomycin: Limitation of use

A

Do not use for pneumonia (messes up surfactant)

42
Q

Only cephalosporin with activity against MRSA

A

Ceftaroline fosamil

43
Q

Dalbavancin: Not active against v___ ____ ___ (__)

A

vancomycin resistant Enterococcus (VRE)

44
Q

Dalbavancin: has a long

A

half life

45
Q

Dalbavancin: Use caution in patients with reported ___ hypersensitivities

A

glycopeptide

46
Q

Dalbavancin: ___ may result in “Red-man” syndrome (similar to vancomycin

A

Infusion times faster than the recommended 30 minutes

Pharm (23 decks)

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