corticosteroids Flashcards
Corticosteroids work by
inhibiting the release of inflammatory mediators
When applied to inflamed skin, steroids inhibit the ____ of macrophages and leukocytes
migration
Factors that increase absorption: h____
hydration
Factors that increase absorption: o___ d___
Occlusive dressings
Factors that increase absorption: i___ and c____
Infants and children; increased absorption due to increased body surface area
formulas: ___ are more occlusive, therefore more potent
Ointments (o for occlusive)
Gels, aerosols, lotions and solutions are useful in
hair-bearing areas
how long should you use Very high potency
less than 3 weeks
steroids are Contraindicated: As ___ in primary bacterial infections, rosacea, or acne vulgaris
monotherapy
steroids are Contraindicated: Use of high or very-high potency agents on
face, groin, or axilla
Corticosteroids: Prolonged ophthalmic use may cause steroid-induced
glaucoma and cataracts
Corticosteroids: Pregnancy Category
C
Corticosteroids: Use in children can result in H___, c___, i___
hypothalamic-pituitary-adrenal (HPA) asix suppression, Cushing’s syndrome, and intracranial hypertension
Corticosteroids: Chronic high-dose corticosteroid therapy in children may suppress
growth
Corticosteroids: Adverse Drug Reactions: __pigmentation
Hypopigmentation
Corticosteroid Tolerance; may be reversed by
cycling application
Corticosteroids: Systemic effects; ___ failure increases risk
liver
Topical corticosteroids have a repository effect-
with continuous use, prolonged action with less frequent applications
discontinuing long term high-potency corticosteroids
Do not abruptly discontinue after long term high-potency use-> rebound effect may occur; tapering can prevent this
Treatment with very -high potency should not exceed 2 consecutive weeks due to risk of
HPA axis suppression
Proper occlusive dressing application
Wash area then soak in water; apply medication to moist skin and gently rub; cover with plastic wrap. Limit to 12-24 hours
Prescribe Lower-potency for
application to large areas of the body, and for areas that may be more sensitive, such as the face, eyelids, and groin area.
Prescribe Medium-potency for
more severe cases of dermatitis, as well as eczema and scabies
Prescribe High-potency for
thick-skinned areas or lesions due to their enhanced penetration
