Topic 12 - Cardiovascular Sytem (last 3 pages) Flashcards
Anatomy of blood vessels
List the general structure of blood vessels (except capillaries)
4 parts:
- tunica externa
- tunica media
- tunica intima/interna
- lumen
Anatomy of blood vessels
tunica externa
CT
Anatomy of blood vessels
Tunica media
- smooth muscle
- elastic fibers (CT)
Anatomy of blood vessels
Tunica intima/interna
endothelium (simple squamous epithelium)
Anatomy of blood vessels
Lumen
- contains blood
- not a layer
Name the 5 types of blood vessels
(from heart and back to heart)
- arteries
- arterioles
- capillaries
- venules
- veins
Anatomy of blood vessels
starts at the:
heart
Anatomy of blood vessels
from the heart to
elastic arteries
Anatomy of blood vessels
from elastic arteries to
muscular arteries
Anatomy of blood vessels
from muscular arteries to
arterioles
from arterioles to
capillaries
Anatomy of blood vessels
from capillaries to
venules
Anatomy of blood vessels
from venules to
veins
Anatomy of blood vessels
from veins to
heart
Anatomy of blood vessels
Arteries
- name the function
- how many types
- carries blood away from heart (does not refer to oxy or deoxy)
- 2 types
Anatomy of blood vessels
what are the 2 types of arteries?
- elastic arteries
- muscular arteries
Anatomy of blood vessels:
Arteries: elastic arteries
- elastic CT in all 3 layers
- largest arteries (near heart)
- e.g. aorta
Anatomy of blood vessels
arteries: muscular arteries
- a LOT of smooth muscle
- most arteries
- e.g. coronary arteries
aorta refers to
a) elastic arteries
b) muscular arteries
elastic arteries
coronary artery refers to
a) elastic arteries
b) muscular arteries
muscular arteries
largest arteries (near heart) refers to
a) elastic arteries
b) muscular arteries
elastic arteries
most arteries refers to
a) elastic arteries
b) muscular arteries
muscular arteries
a LOT of smooth muscle refers to
a) elastic arteries
b) muscular arteries
muscular arteries
anatomy of blood vessels: blood vessel types
arterioles
- _____ arteries
- what does it regulate?
- little arteries
- regulates blood flow + blood pressure
anatomy of blood vessels: blood vessel types
capillaries
- only contains what layer + ___________
capillaries only have tunica intima - endothelium (one cell layer) + basement membrane
anatomy of blood vessels: blood vessel types
capillaries
- allows what?
- gaps allow?
- capillaries?
- allows exchange of gases + nutrients
- gaps allow limited fluid + solutes toleak out = interstitial fluid (ISF)
- capillaries unite to form venules
anatomy of blood vessels: blood vessel types
venules
- intima, thin media, thin externa
anatomy of blood vessels: blood vessel types
veins
- large lumen
- valves prevent backflow of blood
- thin media - less smooth muscle
- can collapse
anatomy of blood vessels: blood vessel types
veins:
valves prevent what?
backflow of blood
anatomy of blood vessels: blood vessel types
veins
- thin media - less smooth muscle:
- can do what?
can collapse
large lumen refers to:
a) arterioles
b) capillaries
c) venules
d) veins
veins
- intima, thin media, thin externa* refers to
a) arterioles
b) capillaries
c) venules
d) veins
venules
ONLY tunica intima - endothelium (one cell layer) + basement membrane
a) arterioles
b) capillaries
c) venules
d) veins
capillaries
allow exchange of gases + nutrients refers to:
a) arterioles
b) capillaries
c) venules
d) veins
capillaries
gaps allow limited fluid + solutes to leak out = ISF refers to
a) arterioles
b) capillaries
c) venules
d) veins
capillaries
little arteries refers to
- a) arterioles*
- b) capillaries*
- c) venules*
- d) veins*
arterioles
regulates blood flow + blood pressure refers to
a) arterioles
b) capillaries
c) venules
d) veins
arterioles
Blood (CT)
characteristics (4)
- viscosity?
- temperature?
- pH?
- Litres
- higher viscosity than H2O
- 37ºC
- pH 7.35 - 7.45
- 4-6L in an adult
Blood CT
Composition Overview:
- plasma (matrix)
- formed elements
Blood CT: Composition Overview:
Plasma (matrix)
fluid portion with solutes
Blood CT: Composition Overview:
Formed elements
cellular portion
blood (CT): composition detail
Plasma (matrix) = ?
blood minus formed elements
blood (CT)
plasma is composed of:
- H2O - 90%
- Proteins - 8%
- Other solutes - 2%
plasma is composed of proteins - 8%
1.
2.
3.
- albumin
- fibrinogen
- globulin
plasma is composed of proteins - 8%
albumin
control tissue water balance
plasma is composed of proteins - 8%
fibrinogen
clot formation
plasma is composed of proteins - 8%
globulin
antibodies
control tissue water balance refers to
a) albumin
b) fibrinogen
c) globulin
albumin
plasma is composed of
- H2O - 90%
- Proteins - 8%
- Other solutes - 2%
Name the other solutes
- nutrients
- hormones
- wastes
- electrolytes
- gases
Blood (CT): Composition Detail:
Formed elements
Name the 3 types of formed elements:
- RBC - erythrocytes
- WBC - leukocytes
- Platelets
Blood
Formed Elements: RBC - Erythrocytes
- what = % of blood volume that is RBC (45%)
- what is the shape
- what happens when mature?
- life span
- destroyed where?
- hematocrit
- biconcave disc shape
- anucleate when mature
- lifespan - 120 days
- destroyed in the liver & spleen
Formed elements: RBC - Erythrocytes
Hematocrit = ?
% of blood volume that is RBC (45%)
what is the shape of RBC - erythrocytes?
biconcave disc shape
anucleate when mature
erythrocytes
life span of RBC - Erythrocytes
120 days
destroyed in the liver and spleen
RBC - Erythrocytes
What do RBC/Erythrocytes contain?
- Hemoglobin (pigment protein)
Hemoglobin
Heme = ?
- red pigment
- contains iron (Fe)
- attaches and transports O2
Formed elements: RBC/Erythrocytes
Hemoglobin
Globin =
- protein
- attaches and transports CO2
heme is further broken down to _______
bilirubin
globin to _______
amino acids
Formed Elements
WBC - Leukocytes
- nucleated or uninucleated?
- life span
- defend what
- how many types?
- nucleated
- life span varies - days to years
- defend against disease
- 2 types
what is the life span of leukocytes?
days to years
are leukocytes nucleated or uninucleated?
nucleated
this type of formed element defends against disease
WBC - leukocytes
Formed element: WBC - Leukocytes
what are the 2 types of leukocytes
- Granulocytes
- Agranulocytes
Formed Elements: WBC - Leukocytes
Granulocytes
include:
list percentage of each
- neutrophils (60%)
- eosinophils (3%)
- basophils (1%)
Formed Elements: WBC - Leukocytes
Granulocytes: Neutrophils (60%)
- all phagocytic (engulf + digest invaders)
- kill bacteria
Formed Elements: WBC - Leukocytes
Granulocytes: Eosinophils (3%)
attack parasites (e.g. worms)
Formed Elements: WBC - Leukocytes
Granulocytes: Basophils (1%)
release histamine and hepraine
histamine = increase inflammation
heparin = decrease local clotting
histamine
increase inflammation
heparin
decrease local clotting
all phagocytic (engulf + digest invaders)
a) neutrophils
b) eosinophils
c) basophils
neutrophils
release histamine and heparine
a) neutrophils
b) eosinophils
c) basophils
basophils
kill bacteria
a) neutrophils
b) eosinophils
c) basophils
neutrophils
attack parasites (e.g. worms)
a) neutrophils
b) eosinophils
c) basophils
eosinophils
Formed elements: WBC - Leukocytes
Agranulocytes
include:
list the percentage
- lymphocytes (35%)
- monocytes (5%)
Formed elements: WBC - Leukocytes
Agranulocytes
include: lymphocytes (35%)
- how many types?
- name the types
- 2 types
- T lymphocytes
- B lymphocytes
Formed elements: WBC - Leukocytes
Agranulocytes
include lymphocytes:
-
T lymphocytes
- kill what and how?
- B lymphocytes
kill infected/diseased cells directly
Formed elements: WBC - Leukocytes
Agranulocytes
include lymphocytes:
- T lymphocytes
- B lymphocytes
- become what? which produce?
become plasma cells and produce antibodies (globulin)
Formed elements: WBC - Leukocytes
Agranulocytes : Monocytes (5%)
- enters where to become what?
enter tissue + enlarge to become macrophages
(phagocytic = “big eaters”)
immunity refers to
a) granulocytes
b) neutrophils
c) monocytes
d) lymphocytes
e) agranulocytes
lymphocytes
technically lymphocytes are part of agranulocytes as well
which formed element enter tissue + enlarge to become macrophages
a) T lymphocytes
b) Granulocytes
c) Monocytes
d) B lymphocytes
monocytes
name all the possible Leukocytes
even the subtypes
- Granulocytes
- neutrophils
- eosinophils
- basophils
- Agranulocytes
- lymphocytes
- T lymphocytes
- B lymphocytes
- Monocytes
- lymphocytes
formed elements
platelets
- fragments…
- involved in….
- life span
- fragments of cells called megakaryocytes
- involved in clotting
- life span = 2-10 days
megakaryocytes
fragments of cells
involved in clotting
a) T lymphocytes
b) B lymphocytes
c) Neutrophils
d) Platelets
e) Basophils
platelets
formation of blood cells
Hemopoiesis/Hematopoiesis
Hemopoiesis/Hematopoiesis
- all blood cells arise…
- all blood cells arise indirectly from hemocytoblast cells (=stem cells) in red bone marrow
hemocytoblast cells =
stem cells
all blood cells arise indirectly or directly from hemocytoblast cells in red bone marrow
indirectly
red marrow in adult:
- ?
- ?
- ?
- axial skeleton
- pelvic + pectoral girdles
- proximal ends of humerus + femur
life span of platelets?
2 - 10 days
platelets are fragments of cells called _______
megakaryocytes