thyroid biochemistry Flashcards
which thyroid hormone is biologically active?
T3
what is the layer of epithelium cells surrounding the central cavity?
thryoid follicle
which side of the thyroid follicle faces the bloodstream?
the basolateral side
thyroglobulin is synthesized in _____, secreted/stored in the _____
follicular cells; colloid
in the organification of iodide, what oxidizes iodide?
thyroid peroxidase
what hormone is responsible for coupling of iodotyrosyl residues of thyroglobulin to make T3/T3?
TPO (thyroid peroxidase)
pyroglutamyl-histidyl-proline residues make up?
TRH
TRH signaling uses what type of signaling?
G-protein coupled receptor–>activates phospholipase C protein
glycoprotein & heterodimer describes?
TSH
half life of TRH:____, half life of TSH:____
TRH: 3 min
TSH: 65 min
where is the receptor for TSH on the thyroid follicular cell?
basolateral memrbane
what does TSH signal
cAMP protein kinases
which carrier protein has a high affinity for T4?
globulin
what are the major transport proteins for thyriod hormones in blood? (4)
- globulin
- albumin
- transthyretin
- lipoproteins
which deiodinase has both outer and inner phenyl ring activity towards T4?
type 1 deiodinase
which deiodinase is located in the liver, kidney, thryoid?
type 1
type ____deiodinase has outer ring activity, whereas type ____deiodinase has inner ring activity
2; 3
which deiodinase has activity towards T3?
type 3
which deiodinase can produce T3 (2)?
Type 1, Type 2
which deiodinase functions to inactivate thyroid hormones?
type 3
which deiodinase has vast tissue distribution?
type 2
