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Endocrine > thyroid biochemistry > Flashcards

thyroid biochemistry Flashcards

1
Q

which thyroid hormone is biologically active?

A

T3

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2
Q

what is the layer of epithelium cells surrounding the central cavity?

A

thryoid follicle

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3
Q

which side of the thyroid follicle faces the bloodstream?

A

the basolateral side

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4
Q

thyroglobulin is synthesized in _____, secreted/stored in the _____

A

follicular cells; colloid

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5
Q

in the organification of iodide, what oxidizes iodide?

A

thyroid peroxidase

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6
Q

what hormone is responsible for coupling of iodotyrosyl residues of thyroglobulin to make T3/T3?

A

TPO (thyroid peroxidase)

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7
Q

pyroglutamyl-histidyl-proline residues make up?

A

TRH

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8
Q

TRH signaling uses what type of signaling?

A

G-protein coupled receptor–>activates phospholipase C protein

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9
Q

glycoprotein & heterodimer describes?

A

TSH

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10
Q

half life of TRH:____, half life of TSH:____

A

TRH: 3 min
TSH: 65 min

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11
Q

where is the receptor for TSH on the thyroid follicular cell?

A

basolateral memrbane

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12
Q

what does TSH signal

A

cAMP protein kinases

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13
Q

which carrier protein has a high affinity for T4?

A

globulin

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14
Q

what are the major transport proteins for thyriod hormones in blood? (4)

A
  1. globulin
  2. albumin
  3. transthyretin
  4. lipoproteins
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15
Q

which deiodinase has both outer and inner phenyl ring activity towards T4?

A

type 1 deiodinase

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16
Q

which deiodinase is located in the liver, kidney, thryoid?

A

type 1

17
Q

type ____deiodinase has outer ring activity, whereas type ____deiodinase has inner ring activity

A

2; 3

18
Q

which deiodinase has activity towards T3?

A

type 3

19
Q

which deiodinase can produce T3 (2)?

A

Type 1, Type 2

20
Q

which deiodinase functions to inactivate thyroid hormones?

A

type 3

21
Q

which deiodinase has vast tissue distribution?

A

type 2

Endocrine (31 decks)

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