hypersecretion of ant pit hormones Flashcards
what hormones are vital to human existence?
TSH, ACTH
which ant pit hormones do not have simple end organ feedback inhibitory loops?
GH, prolactin
which ant pit hormones do have simple end organ feedback inhibitory loops?
ACTH, TSH, FSH, LH
prolactin excess leads to (2)?
galactorrhea, hypogonadism
what causes hypogonadism?
inhibition of gnrh
post-menopausal woman, HA, visual field problems
large pit tumor
serum prolactin under 30?
stress
serum prolactin >300
pit adenoma
serum prolactin >100 and not preg
usu adenoma
what is the most common type of fxnal pit adenoma?
prolactinomas
is micro or macro prolactinoma more common?
micro
tx for micro prolactinoma if sx?
bromocriptine (DA agonist)
common cause of hypoprolactinemia
sheehan’s syndrome
what GH excess happens before ephiphyseal closure in peds?
gigantism
what is an insidious, chronic disease assc’d with boney and soft tissue overgrowth, middle aged ppl?
acromegaly
sx of GH excess usu present how many yrs before dx?
7-8 years
what test is req’d for dx GH excess?
GH inhibition test with standard glu load
tx of GH excess?
surgery–>transphenoidal
are slow growing or rapidly growing tumors of the hypothalamus more common?
slow growing
which hypothalamic tumor: more likely to produce dementia, food intake disturbances, endocrine dysfxn
slow growing
which hypothalamic tumor: more likely to produce coma, ANS dysfxn
fast growing
what to check if failure to lactate?
stimulation test with TRH or chlorpromazine
