hypopituitarism Flashcards

1
Q

a majority of cases of hypopituitarism are due to?

A

pituitary disease >hypothalamic disease > idiopathic

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2
Q

post pregnancy w/ post-partum hemorrhage, inability to lactate or return to normal menses, lethargy, anorexia, weight loss

A

sheehan’s syndrome

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3
Q

when a pituitary adenoma hemorrhages into itselt

A

pituitary apoplexy

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4
Q

sudden onset of excruciating pain, diplopia due to pressure on oculomotor nerves

A

pituitary apoplexy

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5
Q

lymphocytic invasion followed by destruction of pit cells occuring late pregnancy or post-partum

A

lymphocytic hypophysitis

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6
Q

is primary or secondary empty sella syndrome more commonly assc’d with hypopituitarism?

A

secondary

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7
Q

low cortisol, low ACTH, does not result in aldosterone deficiency

A

secondary adrenal insufficiency

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8
Q

does primary or secondary Adrenal insufficiency result in hyperpigmentation?

A

primary

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9
Q

what is a deficient morning cortisol reading?

A

under 3

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10
Q

what is a normal morning cortisol?

A

> 18

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11
Q

tx for ACTH deficiency

A

hydrocortisone 15-30 mg daily

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12
Q

secondary hypothyroidism presents with ___T4 and ____TSH

A

low T4, low TSH

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13
Q

tx for TSH deficiency

A

L-thyroxine

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14
Q

what is unneccesary to measure in secondary hypothyroidism

A

TSH (it will always be low)

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15
Q

what to measure if woman presents with abnormal menstrual cycles

A

estradiol, LH, FSH

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16
Q

estradiol, LH, FSH are expected to be _____ in gonadotropin deficiency

A

low

17
Q

what is the most common measurement of GH deficiency?

A

IGF-1

18
Q

likelihood of deficiencies in panhypopituitarism

A

GH > LH/FSH > TSH> ACTH

19
Q

how to tx GH deficiency

A

recombinant human growth hormone

20
Q

what are the 2 things that stimulate vasopressin release?

A
  1. increase in plasma osmolality

2. decr in plasma volume

21
Q

where are the V1 receptors?

A

vasculature

22
Q

where are the V2 receptors?

A

renal tubules

23
Q

stimulation of V1 receptors?

A

vasoconstriction

24
Q

stimulation of V2 receptors ____permeability of renal tubules

A

increases

25
Q

when to admin desmopressin

A

if central diabetes insipidis & if urine volumers >4 L /day

26
Q

desmopressin/ddAVP is specific to what type of receptor?

A

V2

27
Q

serum prolactin under 200 = prolactinoma of what size?

A

under 1 cm

28
Q

serum prolactin 200-1000 = prolactinoma of what size?

A

1-2 cm

29
Q

serum prolactin >1000 = prolactinoma of what size?

A

> 2 cm

30
Q

prolactin levels under 100 are caused by stalk compression or prolactinoma?

A

stalk compression

31
Q

in prolactinomas, prolactin levels are _____

A

proportional to size of tumor