adrenal insufficiency Flashcards
adrenal androgens are made in the ___ and ____
zona fasciculata and reticularis
are deficiencies in DHEA common?
no, b/c majority of androgens are made in testes and ovaries
renin is produced where?
justaglomerular cells of afferent arterioles
ACE is converted where?
endothelium of lung capillaries
ACTH is synthesized as part of larger precursor molec called?
POMC
what does POMC get cleaved into (3)
- ACTH
- lipotropin
- melanocyte stimulating hormone
how to tx primary adrenal insufficiency (2)
- fludrocortisone
2. hydrocortisone
most common cause of primary adrenal insufficiency in US
autoimmune destruction
most common cause of primary adrenal insufficiency in the world
TB
primary AI glands from autoimmune destruction are ____, and from TB are____
small, lymphocytic infiltration; large & calcified/granulomatous
normal adrenal response to cortosyn stimulation test
> 18
tx of primary adrenal insufficiency
- hydrocortisone 2x/day
2. fludrocortisone daily
in times of minor stress, what to do with dose of cortisol in PAI?
double dose
5 S’s to tx adrenal crisis
- salt (NS)
- sugar (dextrose)
- steroids
- support
- search for precipitating illness
primary adrenal insufficiency leads to loss of ______, whereas secondary adrenal insufficiency leads to loss of______
aldosterone, corticosteroids;
corticosteroids
