Thrombotic Disorders****

Question 1

3 classes of drugs under Thrombotic Disorder

Answer 1

1. Anti-platelets
2. Anticoagulants
3. Thrombolytics or Fibrinolytics

Question 2

1st Gen: Urokinase & Streptokinase
2nd Gen: Suffix (-teplase) tPA

Answer 2

Thrombolytics or Fibrinolytics

Question 3

↓ TXA2:

Answer 3

Low Dose ASA (platelet COX-1 only)

Question 4

↓ ADP P2Y12 R:

Answer 4

-clo-; -grel or -grelor

Question 5

↑ cAMP by (-)PDE3:

Answer 5

Cilostazol,
Anagrelide &
Dipyridamole

Question 6

↓ GP2b/3a:

Answer 6

ABciximab,
TirofiBAn,
EptifiBAtide

Question 7

↓ PAR1:

Answer 7

Vorapaxar

Question 8

Prevent transient ischemic attack (TIA) and other thrombotic events

Answer 8

ASA (if not tolerated, Clopidogrel)

Question 9

Treatment of intermittent CLAUDICATION

Answer 9

Cilostazol (Vasodilator)

Question 10

Dalteparin
Enoxaparin
Fondaparinux

Answer 10

LMWH

Question 11

Drugs under Direct IIa Inhibitors

Answer 11

Argatrobran; IV:BIValirudin; Oral: Dabigatran

Question 12

Antidote for Direct IIa Inhibitors

Answer 12

Idarucizumab

Question 13

Drugs under Direct Xa blockers

Answer 13

Suffix: -Xaban
ApiXaban
EdoXaban

Question 14

Antidote for Direct Xa blockers

Answer 14

Andexanet alpha

Question 15

Dissolve clot-thrombolytic (for acute MI)

Answer 15

Suffix: -teplase
Streptokinase, Urokinase

Question 16

Antidote for -teplase (tPA)

Answer 16

Aminocaproic Acid
Tranexamic Acid