RPh, April 2024

Question 1

2 Types of Cholinergic Agonist

Answer 1

1. Direct Acting
2. Indirect Acting

Question 2

Drugs under Cholinergic Agonist (Direct Acting)

Answer 2

ends with -chol
Bethanecol
Carbachol
Methacoline
Cevimeline
Pilocarpine

Question 3

Drugs under Cholinergic Agonist (Indirect Acting)

Answer 3

Short Acting - Edrophonium

Intermediate Acting -stigmines (Physostigmine, Neostigmine, Rivastigmine)

Long Acting - Orghanophosphate

Question 4

2 Types of Anti-cholinergic Agonist

Answer 4

1. Non-selective
2. Slective

Question 5

Drugs under Anti-cholinergic Agonist (Non-Selective)

Answer 5

Atropine & Homotropine
Benztropine
Ipratropium & Tiotropium
Scopolamine
Cyclopentolate

Question 6

Drugs under Anti-cholinergic Agonist (Selective)

Answer 6

M1 - Pirenzepine
M3 -fenacin & -terodine (Darifenacin, Solifenacin, Tolterodine, Fesoterodine)

Question 7

2 Types of Sympathetic Agonists

Answer 7

1. Direct Acting
2. Indirect Acting

Question 8

Drugs under Sympathetic Agonist (Direct-Acting)

Answer 8

Alpha 1 (Phenylephrine, Midodrine)

Alpha 2 (MCGG)

Beta Agonist (SABA & LABA)

Mixed-Acting (PPA, Ephedrine)

Question 9

↑ ENZYME activity
↑ drug METABOLISM
↓ PLASMA concentration
Result: ↓ (lesser) activity

Ex. St. John’s wort

Answer 9

Enzyme InDucers

Question 10

↓ ENZYME activity
↓ drug METABOLISM
↑ PLASMA concentration
Result: ↑ activity/lead to toxicity

Ex. Grapefruit Juice

Answer 10

Enzyme InhIbition

Question 11

Is it First or Zero order kinetics?

• Alcohol
• ASA
• Phenytoin

Answer 11

Zero Order Kinetics

Question 12

Gold standard for measuring GFR

Answer 12

Inulin clearance

Question 13

MORE COMMON procedure used to estimate the GFR

Answer 13

Creatinine clearance

Question 14

Quadruple therapy for H. pylori

Answer 14

1. PPIs
2. Metronidazole
3. Tetracycline
4. Bismuth Subsalicylate

Question 15

In Quadruple therapy for H. pylori, if Bismuth is not available, what is the other choice?

Answer 15

1. PPIs
2. Metronidazole
3. Amoxicillin
4. Clarithromycin

Question 16

(-)NK1 R

Answer 16

-pitant (Aprepitant)

Question 17

(-)ACh R

Answer 17

Scopolamine

Question 18

(-)DA2 R

Answer 18

Metoclopramide

Question 19

(-) H1 R

Answer 19

Doxylamine (in combination wIth Vit. B6)
- for pregnant experiencing n&v

Question 20

1. First line for RA
2. If not tolerated

Answer 20

1. Methotrexate
2. Leflunomide

Question 21

First line for OA

Answer 21

NSAIDs (Paracetamol)

Question 22

Histamine precursor

Answer 22

Histidine

Question 23

Serotonin precursor

Answer 23

Tryptophan

Question 24

Aka B-hypophamine

Answer 24

Vasopressin

Question 25

Aka a-hypophamine

Answer 25

Oxytocin

Question 26

Which is preferred drug entry into human milk?

Answer 26

1. High MW
2. Low lipid soluble
3. Short t50
4. Bound
5. Low pKa

Question 27

Huntington’s Disease Tx:

Answer 27

1. Haloperidol
2. Tetrabenazine (only FDA approved
   drug for chorea associated with Huntington’s Disease)

Question 28

Tourette Syndrome Tx:

Answer 28

First line: Haloperidol, Pimozide, and Aripiprazole

Question 29

Multiple Sclerosis

Answer 29

First line: Interferon B-1b or Teriflunomide
Second line: Natalizumab, Daclizumab, Mitoxantrone

Question 30

Amyotrophic Lateral Sclerosis aka: Lou Gehrig Disease

Answer 30

Riluzole (1st drug approved)