Autocoids***

Question 1

BESH

Answer 1

Bradykinin
Eicosanoid
Serotonin
Histamine

Question 2

histamine precursor

Answer 2

Hsitidine

Question 3

Serotonin precursor

Answer 3

Tryptophan

Question 4

Eicosanoid precursor

Answer 4

Arachidonic acid

Question 5

Aka β-hypophamine

Answer 5

Vasopressin/ADH

Question 6

Aka α-hypophamine

Answer 6

Oxytocin

Question 7

↑ bradykinin leads to

Answer 7

dry cough (ACEIs)

Question 8

Most potent constrictor

Answer 8

Endothelin

Question 9

What are the Serotonins

Answer 9

5-HT1b/1d
5HT2A
5-HT3
5-HT4

Question 10

Partial agonists: (-triptans)
Mgt. acute migraines
Triptans = migraines

Answer 10

5-HT1b/1d

Question 11

Blockers: atypical antipsychotics (OlanZAPINE)

Answer 11

5HT2A

Question 12

Effect: N & V
Blockers: (-setron)

Answer 12

5-HT3

Question 13

Effect: ↑ peristalsis
Agonist: Tegaserod (IBS-C)

Answer 13

5-HT4

Question 14

✓ Effects: vasodilation, edema, allergy
✓ Blockers: Diphenhydramine (Anti-histamine)

Answer 14

H1

Question 15

✓ Effect: ↑ acid secretion = ulcer
✓ Blockers: Cimetidine

Answer 15

H2

Question 16

✓ PATENCY of ductus arteriosus; treatment
of erectile dysfunction***

Answer 16

PGE1 analog
(Alprostadil)

Question 17

✓ anti-ulcer; abortifacient
✓ PGE1 analog

Answer 17

Misoprostol

Question 18

✓ Abortifacient (FDA-approved)

Answer 18

PGE2 analog
(Dinoprostone)