The specific immune system 12.6 Flashcards
What are antigens
- protein molecules present on the surface of cells which trigger immune responses
What are antibodies
- Y-shaped glycoproteins called immunoglobulins found in the blood that bind to antigens/toxin
How long does the specific immune system take to respond
- inital invasion can take up to 14 days
- upon seconday invasion, 3-5 days
What is the structure of antibodies
- made of 4 chains in total (2 heavy and 2 light chains)
- disulfide bonds form between heavy and light chains and also between the 2 heavy chains
Explain how antibodies work to bind to antigens
- bind based on lock and key mechanism (complementary antigen and antibody)
What is the variable region
- forms the antibody binding site
- part of the antibody made from both variable light and heavy chain region
What is the constant region
Every part of the antibody except the binding site (variable region)
what is produced when a antigen and antibody bind together
- an antigen-antibody complex
what is the hinge region
- flexible stretch of antibody where heavy and light chains form disulfide bonds
What is the function of the hinge region of an antibody
The hinge region of the antibody provides the molecules with flexibility, allowing it to bind 2 separate antigens, one at each of its antigen-binding sites
- What are agglutinins
- how do they aid immunity
- Chemicals that cause pathogens to clump together
- aiding phagocytosis, helps slow spread of pathogen
What are the different types of lymphocytes
There are T lymphocytes and B lymphocytes
What are the types of T lymophocytes
- T killer cells
- T helper cells
- T memory cells
- T regulator cells
what are the types of B lymphocytes
- Plasma cells
- B effector cells
- B memory cells
Features of T helper cells
- receptors on membranes bind to antigens on APCs
- produce interleukins (type of cell signalling molecule) which stimulate B cells to:
- increase antibody production
- T cell production
- stims phagocytosis of APC
APC= antigen presenting cell
What are T killer cells
- destroy APC
- produce chemical called perforin, which forms holes in the cell membrane so it’s freely permeable
^kills cell
APC=anti-gen presenting cell
features of t memory cells
- live for a long time
- part of the immunological memory.
- If they meet an antigen a second time, they rapidly produce a huge number of T killer cells (clonal expansion) that destroy the pathogen
What are T regulator cells
- cells suppress immune system once pathogen been eliminated
- make sure body recognise self antigens
^interleukins play role in this
what are plasma cells (B lymphocytes)
- cells that produce antibodies to a particular antigen
What are B effector cells
These divide to form plasma cell clones
plasma cells produce antibodies to particular antigens
What are B memory cells
- lives for a very long time
- part of immunological memory
- programmed to remember specific antigen and the antibody that binds to it
^gives body rapid response to pathogen presenting this antigen
What is cell-mediated immunity
- T lymphocytes respond to the cells of an organism that have been changed in some way, for example by a virus infection, by antigen processing or by mutation (for example cancer cells) and to cells from transplanted tissue
What are the steps of the cell-mediated response
1)In the non-specific defence system, macrophages engulf and digest pathogens in phagocytosis. They process the antigens from the surface of the pathogen to form antigen-presenting cells (APCs).
2)The receptor on some of the T helper cells fit the antigens. These T helper cells become activated and produce interleukins, which stimulate more T cells to divide rapidly by mitosis. They form clones of identical activated T helper cells that all carry the right antigen to bind t a particular pathogen
3)The cloned T cells may:
- develop into T memory cells, which give a rapid response if this pathogen invades the body again
- produce interleukins that stimulate phagocytosis
- produce interleukins that stimulate B cells to divide
- stimulate the development of a clone of T killer cells that are specific for the presented antigen and then destroy infected cells.
What is humoral immunity
- Component of immune system involving the production of antibodies by B cells and secreting them into the blood and lymph fluid
