The regulation of the immune response Flashcards
1. What is the major factor regulating the adaptive immune response?
A The neutrophil
B Complement membrane attack complex
C C-reactive protein
D Antigen concentration
E Haptoglobin
D Antigen concentration
2. Which of the following statements is TRUE of antigenic competition?
A Antigenic competition involves competition between T-cell epitopes for the MHC groove
B Antigenic competition is initiated at the pre-T cell stage
C Antigenic competition is unrelated to the concept of dominant and subdominant epitopes
D Antigenic competition can only occur with cryptic epitopes
E Antigenic competition refers to the differential immunogenicity of the carbohydrate and protein moieties in a glycoprotein
A Antigenic competition involves competition between T-cell epitopes for the MHC groove
3. What is negative feedback on adaptive B-cell responses mediated by?
A Antigen-specific IgM
B Antigen specific IgG
C Just antigen neutralization
D Fcγ receptors on macrophages
E F(ab′)2 anti-μ
B Antigen specific IgG
4. Which of the following is an example of an anti-apoptotic molecule?
A Bcl-2
B TRAIL
C Bax
D FADD
E Caspase 8
A Bcl-2
5. Injection of a mouse with a very high dose of sheep erythrocytes induces:
A A generalized antigen non-specific suppression
B Antigen-specific T-cell-mediated suppression
C Class switching to IgM antibody production
D IFNγ production by Th2 cells
E A high antibody response
B Antigen-specific T-cell-mediated suppression
6. Suppression of Th2 by Th1 cells can be mediated by:
A IL-1
B IL-3
C IL-4
D GM-CSF
E IFNγ
E IFNγ
7. Cells bearing MHC class I plus peptide are targets for specific:
A B-cells
B Cytotoxic T-cells
C Th1 cells
D Th2 cells
E Interdigitating dendritic cells
B Cytotoxic T-cells
8. Which of the following statements is TRUE of natural antibodies?
A Natural antibodies are mostly IgG
B Natural antibodies are mostly high affinity autoantibodies
C Natural antibodies are produced spontaneously by CD5+ B-cells
D Natural antibodies are acquired by transplacental passage from the mother
E Natural antibodies do not arise in thymectomized mice
C Natural antibodies are produced spontaneously by CD5+ B-cells
9. Antibodies specific for different epitopes on the same antigen:
A Will usually bind to each other through idiotypic interactions
B Cannot bear similar idiotypes
C Can bear similar idiotypes independently of their antigenic specificity
D Can only bear similar idiotypes if the antigenic epitopes cross-react
E Must be of the same immunoglobulin class
C Can bear similar idiotypes independently of their antigenic specificity
10. An internal image monoclonal anti-idiotype:
A Has specificity for its own internal structure
B Is the mirror image of the idiotype
C Has identical idiotypes on heavy and light chains
D Mimics a single epitope on the antigen
E Cannot function as a “surrogate” antigen
D Mimics a single epitope on the antigen
11. High responder ‘Biozzi’ mice:
A Phagocytose carbon particles faster than low responders
B Were obtained by breeding wild mice through five generations, selectively mating the high responders each time
C Differ from low responders by a single gene
D Produce high titer antibodies to only a very restricted number of antigens
E Produce high titer antibodies to a variety of antigens
E Produce high titer antibodies to a variety of antigens
12. A high antibody response to an antigen such as (TG)-A-L in a given mouse strain:
A Is linked to immunoglobulin gene polymorphism
B Is independent of MHC (H-2) haplotype
C Depends on T-cell recognition of the antigen bound to MHC class II
D Depends on T-cell recognition of the antigen bound to MHC class I
E Reflects a general propensity to make high titer antibody responses
C Depends on T-cell recognition of the antigen bound to MHC class II
13. Which of the following is NEVER related to poor MHC-linked immune response?
A Defective T-cell repertoire
B T-cell-mediated suppression
C Inadequate antigen processing
D Poor binding of peptide epitope to MHC
E Defective V gene rearrangement
E Defective V gene rearrangement
14. Which of the following statements is TRUE of immune responses?
A Immune responses are depressed by stress
B Immune responses are stimulated by glucocorticoids
C Immune responses are depressed by estrogens
D Immune responses are stimulated by androgens
E Immune responses are depressed by growth hormone
A Immune responses are depressed by stress
15. Stimulation of glucocorticoid synthesis by IL-1:
A Provides a basis for a feedback suppressor circuit
B Cannot provide a basis for a feedback suppressor circuit
C Augments IL-1 synthesis
D Augments cell-mediated immunity
E Augments IFNγ synthesis
A Provides a basis for a feedback suppressor circuit
