Membrane receptors for antigen Flashcards
1. What is the first immunoglobulin heavy chain class to be expressed on the surface of a newly produced B-cell?
A IgA
B IgD
C IgE
D IgG
E IgM
E IgM
2. A B-cell is able to make cell-surface and secreted versions of antibody using:
A Different gene pools
B Differential splicing
C Different heavy chain class but the same light chain
D Different light chain class but the same heavy chain
E F(ab′)2 fragments
B Differential splicing
3. What does the cytoplasmic region of cell surface IgM consists of?
A A single H chain constant region domain
B A light chain
C 110–120 amino acids
D Three amino acids
E Carbohydrate
D Three amino acids
4. What is the percentage of human peripheral blood T-cells bearing a γδ T-cell receptor?
A 30–80%
B 1–5%
C 100%
D 0%
E Only present during mycobacterial infections
B 1–5%
5. The T-cell receptor genes were originally identified using:
A A monoclonal anti-idiotype
B The polymerase chain reaction (PCR)
C A liver DNA gene library
D In situ hybridization
E Subtractive hybridization
E Subtractive hybridization
6. A chromosome on which T-cell receptor α chain gene rearrangement has occurred lacks which of the following gene segments?
A Joining (J)
B Diversity (D)
C Variable (V)
D Constant (C)
E T-cell receptor (TCR) β chain
B Diversity (D)
7. Using only random VDJ recombination, from 40 V, 23 D, and 6 J gene segments, what are the number of possible variable regions of an antigen receptor molecule?
A 40
B 69
C 5520
D 1.1 × 106
E 1.3 × 109
C 5520
40 × 23 × 6 = 5520.
8. N-region insertion is associated with the expression of:
A Terminal deoxynucleotidyl transferase.
B NK cell antigen receptors
C The immunoproteasome
D Lysozyme
E Heat shock proteins
A Terminal deoxynucleotidyl transferase.
9. Which of the following statements is TRUE of receptor editing?
A Has been described for antibody but not TCR
B Is associated with reexpression of RAG-1 in germinal centers
C Can involve V genes which are 3′ of the initially selected V gene
D Involves the S (switch) sequences
E For B-cells only occurs in bone marrow
B Is associated with reexpression of RAG-1 in germinal centers
10. Somatic hypermutation of V genes:
A Is confined to the hypervariable regions
B Involves heavy but not light chain immunoglobulin V genes
C Does not occur in IgM antibodies
D Can decrease the affinity of an antibody
E Is commonly seen for both antibody and TCR
D Can decrease the affinity of an antibody
11. NK cells lack receptors with:
A Specificity for MHC class II molecules
B Specificity for MHC class I molecules
C C-type lectin domains
D Immunoglobulin-like domains
E Specificity for the Fc region of IgG
A Specificity for MHC class II molecules
12. The Ly49A receptor on NK cells does NOT:
A Exist as a dimer
B Possess an α-helix in its structure
C Recruit phosphatases
D ITAMS
E ITIMS
D ITAMS
13. What does the MHC class I heavy chain consists of?
A β2-microglobulin
B Three Ig-type domains
C A truncated MHC class II heavy chain
D Three globular domains
E Two globular domains
D Three globular domains
14. What is the molecular weight of MHC class II β chain?
A 28–29 kDa
B 34 kDa
C 43–44 kDa
D 11–12 kDa
E 24–25 kDa
A 28–29 kDa
15. Where are the MHC class II region genes in the mouse located?
A On a different chromosome to the class I region genes
B On a different arm, but on the same chromosome as the class I region genes
C On chromosome 6
D Adjacent to a class I gene
E In the HLA locus
D Adjacent to a class I gene
