Immunodeficiency Flashcards
1. Defects in the neutrophil NADPH oxidase system result in:
A Chronic granulomatous disease
B Chediak–Higashi disease
C Leukocyte adhesion deficiency
D Hashimoto’s disease
E Agammaglobulinemia
A Chronic granulomatous disease
2. Mendelian susceptibility to mycobacterial infection does NOT involve the gene for:
A IFNγR1
B IL-12 p40
C IFNγR2
D MEFV
E IL-12RβI
D MEFV
3. Paroxysmal nocturnal hemoglobulinuria results from deficiency in:
A Myeloperoxidase
B Decay accelerating factor (DAF)
C Classical pathway C components
D C1 inhibitor
E C8
B Decay accelerating factor (DAF)
4. X-linked agammaglobulinemia results from a mutation in:
A IFNγ receptor
B The CIITA promoter protein
C An HLA gene
D CD40L (CD154)
E A tyrosine kinase gene
E A tyrosine kinase gene
5. Di George syndrome results from a defect in:
A Purine nucleoside phosphorylase
B Wiskott–Aldrich syndrome protein (WASP)
C Thymic development
D DNA repair
E CD3
C Thymic development
6. What is the approximate percentage of cases of severe combined immunodeficiency (SCID) due to defects in the Armetis gene?
A 5%
B 10%
C 15%
D 40%
E 60%
C 15%
7. What deficiency is indicated by poor skin test results to a range of microbial antigens such as tuberculin and mumps?
A NK cells
B T-cells
C B-cells
D Phagocytosis
E Opsonization
B T-cells
8. What does HIV binds to?
A CD4
B IL-2 receptor
C NFκB
D Reverse transcriptase
E TNF receptors
A CD4
9. Which of the following is a coreceptor for HIV?
A RANTES
B CD8
C CD54
D CR5
E CXCR4
E CXCR4
10. Which of the following is NOT helpful in the diagnosis of AIDS?
A CD4 numbers
B CD8 numbers
C Skin tests to bacterial antigens
D Lymph node biopsy
E Serum p24 antigen
B CD8 numbers
11 Which of the following HIV antigens provides a potential target for neutralizing antibody?
A rev
B gp120
C Reverse transcriptase
D Protease
E tat
B gp120
12. Primary immunodeficiency producing susceptibility to infection by viruses and molds is caused by:
A B-cell deficiency
B T-cell deficiency
C Phagocyte deficiency
D Complement deficiency
E Eosinophil deficiency
B T-cell deficiency
13. Deletions in the T-cell CD154 (CD40L) gene produce:
A The hyper-IgM syndrome
B X-linked agammaglobulinemia
C Selective IgA deficiency
D Wiskott–Aldrich syndrome
E Deficiency in cytotoxic T-cell activity
A The hyper-IgM syndrome
14. Which of the following have NOT provided examples of secondary immunodeficiency?
A Viral infection
B Lymphoproliferative disorders
C Cytotoxic drugs
D High fat diet
E Low iron diet
D High fat diet
15. Mutations in the gene encoding which of the following most commonly results in severe combined immunodeficiency (SCID)?
A Adenosine deaminase (ADA)
B IL-7 receptor α chain
C Gamma C interleukin receptor component of the interleukin-15 receptor
D RAG-2 (recombination activating gene-2)
E Artemis
C Gamma C interleukin receptor component of the interleukin-15 receptor
