Allergy and other hypersensitivities

Question 1

1. The β chain of the FcϵRI:

A Binds IgE

B Is associated with Lyn

C Contains a GPI-anchor

D Possesses an ITIM sequence

E Is also used by FcϵRII

Answer 1

B Is associated with Lyn

Question 2

2. Which one of the following mast cell products is NOT preformed and therefore has to be newly synthesized?

A Histamine

B Prostaglandin D2

C Heparin

D Neutral protease

E Eosinophil chemotactic factor (ECF)

Answer 2

B Prostaglandin D2

Question 3

3. Lol p 1-11 are allergens cloned from:

A Rye grass pollen

B House dust mite

C House dust mite feces

D Animal danders

E Dermatophagoides pteryonyssinus

Answer 3

A Rye grass pollen

Question 4

4. Type I hypersensitivity can be blocked using:

A Histamine

B An anti-IgA monoclonal antibody

C A monoclonal of mixed antibody class

D Sodium cromoglycate (cromolyn sodium)

E IL-5

Answer 4

D Sodium cromoglycate (cromolyn sodium)

Question 5

5. What is a major unresolved question concerning antibody-dependent cellular cytotoxicity (ADCC)?

A Whether antibody is involved

B Whether it can be carried out by NK cells

C Whether it leads to cell death

D Whether it is complement-dependent

E To what extent it occurs in vivo

Answer 5

E To what extent it occurs in vivo

Question 6

6. Mycoplasma pneumoniae infection can lead to:

A Hashimoto’s thyroiditis

B Agranulocytosis

C Cold hemagglutinin disease

D Thrombocytopenic purpura

E Neonatal alloimmune thrombocytopenia

Answer 6

C Cold hemagglutinin disease

Question 7

7. Maple bark stripper’s disease is a hypersensitivity largely affecting the:

A Skin

B Kidneys

C Nervous system

D Lung

E Platelets

Answer 7

D Lung

Question 8

8. Dead Wuchereria bancrofti can cause:

A Elephantiasis

B Erythema nodosum leprosum

C Serum sickness

D Pigeon fancier’s disease

E Farmer’s lung

Answer 8

A Elephantiasis

Question 9

9. Chronic granuloma represents an attempt by the body to:

A Wall off a site of chronic infection

B Make a site of chronic infection accessible

C Digest antibody–antigen complexes

D Initiate an immune response

E Change from a Th1 to a Th2 type of response

Answer 9

A Wall off a site of chronic infection

Question 10

10. In thyroid autoimmunity, an antibody causing type V hypersensitivity may be present and is directed against:

A Thyroglobulin

B Thyroid peroxidase

C Thyroid-stimulating hormone (TSH) receptor

D Acetylcholine receptor

E Thyroxine

Answer 10

C Thyroid-stimulating hormone (TSH) receptor

Question 11

11. Which type of hypersensitivity cannot be transferred with serum antibody?

A Type I

B Type II

C Type III

D Type IV

E Type V

Answer 11

D Type IV

Question 12

12. Anaphylaxis can be triggerred by cross-linking of IgE receptors on:

A Monocytes

B Mast cells

C B-cells

D Eosinophils

E T-cells

Answer 12

B Mast cells

Question 13

13. Rhesus hemolytic disease of the fetus and newborn involves:

A IgE

B Antibody to cell surfaces

C Soluble immune complexes

D Cytokine release from T-cells

E Stimulatory antibodies

Answer 13

B Antibody to cell surfaces

Question 14

14. The Arthus reaction is characterized by an intense infiltration by:

A Mast cells

B Neutrophils

C Eosinophils

D Macrophages

E Langerhans cells

Answer 14

B Neutrophils

Question 15

15. The injection of tuberculin into the skin of a sensitized individual elicits:

A Immune complex glomerulonephritis

B Jarisch–Herxheimer reaction

C Isohemagglutinins

D Jones–Mote sensitivity

E Mantoux reaction

Answer 15

E Mantoux reaction

Question 16

16. What are the major effector molecules involved in type IV hypersensitivity reactions?

A Antibodies

B Complement components

C Cytokines

D Prostaglandins

E 5-hydroxytryptamine (5-HT)

Answer 16

C Cytokines

Question 17

17. Septic shock associated with Gram-negative bacteria is primarily caused by:

A Lipopolysaccharide

B Enterotoxin superantigen

C Platelet aggregation

D Switch off of cytokine release

E Peptidoglycans

Answer 17

A Lipopolysaccharide

Question 18

18. The single best description of an allergen is that it is:

A A type of antigen involved in type III hypersensivity

B A molecule recognized by antibody

C A molecule capable of activating B lymphocytes

D A molecule that binds to antibodies sensitizing the surface of mast cells

E A type of antigen involved in type II hypersensivity

Answer 18

D A molecule that binds to antibodies sensitizing the surface of mast cells

Question 19

19. The single best description of type III hypersensitivity is that it involves:

A Antibodies

B Antigen

C Complement

D Immune complexes

E Macrophages

Answer 19

D Immune complexes

Question 20

20. Of the following, the single best defining description of a type IV hypersensitivity reaction is that it involves:

A Allergen

B Antigen

C Cytokine release

D Cutaneous manifestations

E A delayed type of hypersensitivity

Answer 20

E A delayed type of hypersensitivity