The chemical senses ( olfaction and taste) Flashcards
when you get a severe cold why do we PERCEIVE that food doesn’t taste as good?
because olfaction component of flavor is 1/3 of the flavor perception
why are olfaction and taste problems important to identify in a pt?
b/c they can indicate more general disease ( serious) states.
what is special about the sensory capacity of gustatory (taste) and olfactory receptors?
they can maintain sensory capacity despite death of old receptor elements and recruitment of new elements ( new olfactory neurons and new taste receptor cells respectively).
Where does a large % of CSF flow out of in the olfaction/gustatory system and what is the implication of this?
the cribiform plate and this is a problem because it serves as a conduit for viruses to get into the nervous system.
where are the olfactory cell bodies located?
in the olfactory epithelium lining below the cribiform plate
where do the axons of the olfactory system travel to relay info?
via the axonal projections through the cribiform plate to the olfactory bulb
what are the 4 olfactory bulb targets?
pyriform cortex ( olfactory cortex), olfactory tubercle, amygdala, entorhinal cortex
from the amygdala where in the brain does the olfactory neuron travel?
orbitofrontal cortex ( emotional association),thalamus and hypothalamus
from the entorhinal cortexwhere in the brain does the olfactory neuron travel?
hippocampal formation ( memory association)
what capacity do olfactory epithelial basal cells have ?
they can replenish epithelium as mature sensory neurons die
what is anosmic?
can’t smell
what is parosmia
a change in the perception so that something doesn’t smell the way it usually does ( this can happen after exposure to extreme toxins b/c the neurons die and regenerate but regenerate incorrectly.)
How long do sensory neruons last?
30 days
what is the largest g protein coupled system in the body?
olfaction
when an odorant interacts with a receptor protein what happens?
depolarization of the receptor potential occurs and cAMP increases via activation od adenly cyclase , cAMP binds an ion channel and opens it depolarizing the cell and letting Ca2+ in .
Ca2+ leads to Cl- channel opening which gives the olfactory signal a boost.
how many olfactory receptors do we have?
1000s
explain the specificity of odor receptors
they have some specificity but are promiscuous, i.e. compounds with similar chemical structure may use similar or same receptors.
There isn’t an orange or a rose receptor.
what is the structure of the olfactory receptor?
a 7 transmembrane domain. all receptors have amino acid sequence homology.
what is the distribution of the olfactory receptors?
they are split up into quarters with 1/4 residing in each zone.
How many olfactory receptor types does a neuron express?
only one