The chemical senses ( olfaction and taste) Flashcards

1
Q

when you get a severe cold why do we PERCEIVE that food doesn’t taste as good?

A

because olfaction component of flavor is 1/3 of the flavor perception

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2
Q

why are olfaction and taste problems important to identify in a pt?

A

b/c they can indicate more general disease ( serious) states.

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3
Q

what is special about the sensory capacity of gustatory (taste) and olfactory receptors?

A

they can maintain sensory capacity despite death of old receptor elements and recruitment of new elements ( new olfactory neurons and new taste receptor cells respectively).

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4
Q

Where does a large % of CSF flow out of in the olfaction/gustatory system and what is the implication of this?

A

the cribiform plate and this is a problem because it serves as a conduit for viruses to get into the nervous system.

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5
Q

where are the olfactory cell bodies located?

A

in the olfactory epithelium lining below the cribiform plate

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6
Q

where do the axons of the olfactory system travel to relay info?

A

via the axonal projections through the cribiform plate to the olfactory bulb

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7
Q

what are the 4 olfactory bulb targets?

A

pyriform cortex ( olfactory cortex), olfactory tubercle, amygdala, entorhinal cortex

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8
Q

from the amygdala where in the brain does the olfactory neuron travel?

A

orbitofrontal cortex ( emotional association),thalamus and hypothalamus

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9
Q

from the entorhinal cortexwhere in the brain does the olfactory neuron travel?

A

hippocampal formation ( memory association)

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10
Q

what capacity do olfactory epithelial basal cells have ?

A

they can replenish epithelium as mature sensory neurons die

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11
Q

what is anosmic?

A

can’t smell

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12
Q

what is parosmia

A

a change in the perception so that something doesn’t smell the way it usually does ( this can happen after exposure to extreme toxins b/c the neurons die and regenerate but regenerate incorrectly.)

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13
Q

How long do sensory neruons last?

A

30 days

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14
Q

what is the largest g protein coupled system in the body?

A

olfaction

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15
Q

when an odorant interacts with a receptor protein what happens?

A

depolarization of the receptor potential occurs and cAMP increases via activation od adenly cyclase , cAMP binds an ion channel and opens it depolarizing the cell and letting Ca2+ in .

Ca2+ leads to Cl- channel opening which gives the olfactory signal a boost.

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16
Q

how many olfactory receptors do we have?

A

1000s

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17
Q

explain the specificity of odor receptors

A

they have some specificity but are promiscuous, i.e. compounds with similar chemical structure may use similar or same receptors.

There isn’t an orange or a rose receptor.

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18
Q

what is the structure of the olfactory receptor?

A

a 7 transmembrane domain. all receptors have amino acid sequence homology.

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19
Q

what is the distribution of the olfactory receptors?

A

they are split up into quarters with 1/4 residing in each zone.

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20
Q

How many olfactory receptor types does a neuron express?

A

only one

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21
Q

How are neurons expressing a particular olfactory receptor distributed?

A

homogenously or they can have a clustered distribution pattern

22
Q

How does the number of Odor receptors correlate to the number of odorants?

A

one odor receptor can respond to a lot of different odorants which share a common molecular feature.

23
Q

how do olfactory neurons encode information?

A

by virtue of spatial pattern

24
Q

where do similar patterns of olfactory receptors coalesce?

A

in the glomeruli of the bulb below the cribiform plate

25
Q

what do the mitral and tufted cells in the bulb do?

A

they are relay neurons that project to the olfactory cortex

26
Q

what are periglomerular cells and granule cells?

A

they are inhibitory interneurons that modulate activity of the mitral tufted cells.

27
Q

what is the outermost shell of the olfactory neuron?

A

the periglomerular cells

28
Q

all neurons expressing a particular olfactory receptor______________

A

converge onto the same set of glomeruli

29
Q

what happens to people who have specific anosmias?

A

they can’t discriminate between certain smells

30
Q

what is an odotope?

A

a single chemical moiety that Olfactory receptors recognize ( e.g. a phenyl group)

31
Q

what is the unit for recognizing a particular odotpe?

A

1 glomeruli

32
Q

what is the lateral inhibitory mechanism in the olfactory system?

A

it is the mechanism by which only maximally stimulated sensory neurons ( e.g. an 8 carbon structure) is pass “information” (smell in this case) along, where as incidentally stimulated sensory neurons ( e.g.. given above e.g. 5,6,7,9, and 10 carbon structures) ( activated due to a high stimulus) are filtered out by the granule cells at the level of the mitral and tufted cells so that only the maximally stimulated substance is perceived.

33
Q

what are the 5 tastes qualities?

A

salty, sweet, bitter, sour, and savory ( umami)

34
Q

which cranial nerves innervate the taste buds?

A

VII facial via the chord tympani to tongue and the greater petrosal to the palate ( anterior 2/3 tongue)

and glossopharyngeal ( posterior 1/3 tongue), and vagus ( epiglottis)

35
Q

how many taste cells does each axon innervate?

A

2-10 taste cells

36
Q

what do gustatory axons innervate?

A

the nucleus tractus solitarius

37
Q

after the information from the neurons for taste travel tothe NTS in the brain, where does it go?

A

to the ventral posterior medial (VPM) nucleus of the thalamus and from there to the hypothalamus, and amygdala.

38
Q

what are the taste buds of the soft palate , circumvallate, foliate and fungiform papillae, most sensitive to?

A

sweet

39
Q

where is sweet and savory ( umami) most sensitive?

A

the anterior portion of the tongue

40
Q

where is salty most sensitive?

A

the anterior perimeter of the tongue

41
Q

where is sour most sensitive?

A

the lateral tongue

42
Q

where is bitter most sensitive?

A

the posterior of the tongue

43
Q

where are the taste buds located?

A

in specialized protrusions called papillae

44
Q

Describe taste receptors

A

they are taste receptor cells not neurons and they last 10 days after which the basal cells replenish them ( self renewal)

45
Q

which 2 tastes are transduced through ionic transduction which results in an increase in calcium and transmitter release?

A

salt ( Amiloride -sensitive sodium channel) and sour (H+ -sensitive channel)

46
Q

What tastes are transducer via second messenger ?

A

bitter,sweet and umami.

increase in cAMP–> stimulation of a TRPM5 Ca2+ channel via IP3

47
Q

What is the heterodimer in the second messenger sys for sweet?

A

T1R2 and T1R3

48
Q

What is the heterodimer in the second messenger sys for umami?

A

T1R3 and T1R1

49
Q

What is the homodimer n the second messenger sys for bitter?

A

T2R

50
Q

How does the trigeminal nerve contribute to taste/

A

it contributes pungency ( irritation ), which is activated by capcacin in spicy food for e.g..
this must be distinguished from odor and taste

51
Q

what does the labeled line taste coding demonstrate?

A

that if you remove a homo or heterodimer and remove phospholipase C which is in all taste cellsand then replace them both you will get only the one with the homo/heterodimer removed and the rest will not be restored.