CNS neurotransmitters Flashcards
what are the 2 major types of neurotransmitters?
small molecules ( classic neurotransmitters) and neuropeptides
name the three main types and examples of other small molecule ( classical neurotransmitters)
acetylcholine (ACh), amino acids ( glutamate, GABA, glycine), biogenic amines ( dopamine, norepi, and epi)
what is special about the amino acid neurotransmitters, glutamate, GABAand glycine?
they are in every synapse glutamate is excitatory, and GABA and glycine are inhibitory
what are peptide neurotransmitters important for?
transmission and blocking of pain.
what does removal of neurotransmitters from the synapse do?
terminate synaptic transmission
the concentration of neurotransmitter w/in the synaptic cleft is tightly controlled via regulation of what 4 processes?
neurotransmitter synthesis, packaging, release and removal
where are neuropeptide neurotransmitters made?
in the ER
where are small molecule neurotransmitters made?
in the presynaptic terminal
ligand gated ion channels are?
ionotropic
G-prootein coupled channels are?
metabotropic
Metabotropic neurotransmitters are ___________ than ionotropic transmitters
slower
1 alpha and 1 beta are required to be what type of receptor?
GABA
iontoropic receptors have how many subunits that contain how many transmembrane domains?
iontoropic receptors are usually 4-5 subunits that contain 3 or 4 transmembrane domains
metabotropic receptors have how many transmembrane domains?
7
what are the major biogenic amine neurotransmitters?
dopamine, norepinephrine, serotonin
what is the major neurotransmitter in the neuromuscular junction of the peripheral nervous system and where else is it the major neurotransmitter?
acetylcholine which is also the major neurotransmitter in the parasympathetics
where is acetylcholine synapse in the peripheral nervous system?
in the ganglia of the visceral motor sys
what are the fmcs of Ach in the CNS?
attention, arousal, reward plasticity, enhances sensory fnc upon waking
what is damage to the Ach sys ( cholinergic sys) in the CNS associated w/?
memory deficits in alzheimer’s
what does acetylcholinesterase do?
it cleaves acetylcholine to acetate and choline ( this occurs in the synaptic cleft in the CNS and in the basal lamina in the periphery
where is achetocholine degraded?
in the synaptic cleft
sarin gas and other nerve gases and insecticides which inhibit acetylcholinesterase do what?
cause Sch to accumulate resulting in continued depolarization of the postsynaptic cell and leads to muscle paralysis at the neuromuscular junction.
are acetylcholine receptors ionotropic or metabotropic?
there are both metabotropic (muscarinic)and ionotropic (nicotinic) Ach receptors
where do ionotropic (nicotinic) acetylcholine receptors act?
in the periphery in the neuromuscular junction and also in the CNS